{"id":3140,"date":"2021-07-09T10:39:36","date_gmt":"2021-07-09T10:39:36","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3140"},"modified":"2021-08-25T11:34:59","modified_gmt":"2021-08-25T11:34:59","slug":"thrombophilia","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/services\/hereditary-dieseases-detection\/thrombophilia\/","title":{"rendered":"Thrombophilia"},"content":{"rendered":"<div id=\"pl-3140\"  class=\"panel-layout\" ><div id=\"pg-3140-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3140-0\" ><div id=\"pgc-3140-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3140-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3140-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03ac \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03ae\u03be\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03af \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7. \u03a4\u03ad\u03c4\u03bf\u03b9\u03b1 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9:<\/p>\n<ul>\n<li>Factor V Leiden (R506Q)<\/li>\n<li>Prothrombin (G20210A)<\/li>\n<li>MTHFR (C677T and A1298C)<\/li>\n<li>Factor XIII (V34L)<\/li>\n<li>PAI-1 (4G\/5G)<\/li>\n<li>GPI\u03b1 (C-807)<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3140-0-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"1\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3140-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">GENETIC TEST OF THROMBOPHILIA<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"font-weight: 400;\">\u03a0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03cd\u03c1\u03b9\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c4\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd:<\/p>\n<p>\u00a0 \u00a0 \u00a01) \u03c4\u03bf\u03c5 \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1-V (Leiden) G1691A \u03c0\u03ae\u03be\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2,<\/p>\n<p>2) \u03c4\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2 (\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u0399\u0399-G20210A),<\/p>\n<p>3) \u03c4\u03b7\u03c2 \u039f\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 (MTHFR) C677T,<\/p>\n<p>4) \u03c4\u03b7\u03c2 \u039f\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 (MTHFR) A1298C,<\/p>\n<p>5) \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7\u03c2 GPIa C807T,<\/p>\n<p>6) \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bb\u03b1\u03c3\u03bc\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 (PAI-1) 4G\/5G,<\/p>\n<p>7) \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 XIII 34Val\/Leu.<\/p>\n<p style=\"font-weight: 400;\">\u00a0 O \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03bc\u03ad\u03b8\u03bf\u03b4\u03bf PCR \u03c3\u03b5 \u03c0\u03c1\u03b1\u03b3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03c7\u03c1\u03cc\u03bd\u03bf (real-time PCR) \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ce\u03bd \u03bf\u03bb\u03b9\u03b3\u03bf\u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03c9\u03bd \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03c9\u03bd \u03cc\u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03bd\u03c4\u03bf\u03c0\u03b9\u03c3\u03b8\u03b5\u03af \u03bf\u03b9 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03b5 \u03ba\u03ac\u03b8\u03b5 \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf (mutation-specific primers).<\/p>\n<p>&nbsp;<\/p>\n<p><strong>2. \u0391\u03a0\u039f\u03a4\u0395\u039b\u0395\u03a3\u039c\u0391\u03a4\u0391<\/strong><\/p>\n<p><strong>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1-V \u03c0\u03ae\u03be\u03b7\u03c2 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 (V-Leiden)<\/strong><\/p>\n<p>\u0397 \u03b1\u03b9\u03c4\u03af\u03b1 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03c0\u03bf\u03c3\u03bf\u03c3\u03c4\u03cc \u03bc\u03b5 \u03c4\u03b7\u03bd \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf FACTOR V. \u0397 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03c5\u03c4\u03ae \u03c0\u03bf\u03c5 \u03ad\u03c7\u03b5\u03b9 \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03b8\u03b5\u03af (G1691A) \u03b1\u03c6\u03bf\u03c1\u03ac \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03b5\u03bd\u03cc\u03c2 \u03b1\u03bc\u03b9\u03bd\u03bf\u03be\u03ad\u03bf\u03c2 \u03b1\u03c0\u03cc \u03ba\u03ac\u03c0\u03bf\u03b9\u03bf \u03ac\u03bb\u03bb\u03bf. \u03a3\u03c4\u03bf \u03b3\u03b5\u03bd\u03b9\u03ba\u03cc \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03bf 6-10% \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03c1\u03ce\u03bd \u03ba\u03b1\u03b9 \u03b3\u03c5\u03bd\u03b1\u03b9\u03ba\u03ce\u03bd \u039a\u03b1\u03c5\u03ba\u03ac\u03c3\u03b9\u03b1\u03c2 \u03ba\u03b1\u03c4\u03b1\u03b3\u03c9\u03b3\u03ae\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c4\u03b5\u03c1\u03cc\u03b6\u03c5\u03b3\u03bf\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03b1\u03c5\u03c4\u03ae, \u03b5\u03bd\u03ce \u03c0\u03b9\u03bf \u03c3\u03c0\u03ac\u03bd\u03b9\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03c0\u03b5\u03c1\u03af\u03c0\u03c4\u03c9\u03c3\u03b7 \u03bf\u03bc\u03cc\u03b6\u03c5\u03b3\u03c9\u03bd \u03b1\u03c4\u03cc\u03bc\u03c9\u03bd. \u0397 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 V Leiden \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03c4\u03ac 8 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03c4\u03b5\u03c1\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac 80 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03bf\u03bc\u03bf\u03b6\u03c5\u03b3\u03ce\u03c4\u03b5\u03c2. \u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b1\u03b9\u03c4\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af \u03c4\u03b7\u03bd \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03b1\u03c0\u03bf\u03ba\u03b1\u03bb\u03cd\u03c0\u03c4\u03b5\u03b9 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ad\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03c4\u03b7 \u03b4\u03c5\u03bd\u03b1\u03c4\u03cc\u03c4\u03b7\u03c4\u03b1 \u03bb\u03ae\u03c8\u03b7\u03c2 \u03c0\u03c1\u03bf\u03bb\u03b7\u03c0\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03ad\u03c4\u03c1\u03c9\u03bd \u03b3\u03b9\u03b1 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ce\u03bd \u03b8\u03c1\u03bf\u03bc\u03b2\u03ce\u03c3\u03b5\u03c9\u03bd.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03a0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2 (\u03a0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u0399\u0399-G20210A)<\/strong><\/p>\n<p>\u0397 \u03c0\u03c1\u03bf\u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03c1\u03cc\u03b4\u03c1\u03bf\u03bc\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03af\u03bd\u03b7\u03c2, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c4\u03bf\u03bd \u03ba\u03cd\u03c1\u03b9\u03bf \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03b9\u03bc\u03cc\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2. \u0397 \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03b9\u03b4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03bc\u03b9\u03b1\u03c2 \u03b2\u03ac\u03c3\u03b7\u03c2 G \u03c3\u03b5 A \u03c3\u03c4\u03b7 \u03b8\u03ad\u03c3\u03b7 20210 (G20210\u0391) \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03c4\u03b7 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7. \u039f\u03b9 \u03c6\u03bf\u03c1\u03b5\u03af\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 \u03c4\u03c1\u03b5\u03b9\u03c2 \u03c6\u03bf\u03c1\u03ad\u03c2 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b1\u03c2 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 \u03c4\u03b7\u03c2 \u039f\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1\u03c2 (MTHFR)<\/strong><\/p>\n<p>\u0397 \u03c5\u03c0\u03b5\u03c1\u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u03ca\u03bd\u03b1\u03b9\u03bc\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03ac\u03bb\u03bb\u03c9\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2. \u03a4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03b7\u03c2 \u03bf\u03bc\u03bf\u03ba\u03c5\u03c3\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03bf \u03b1\u03af\u03bc\u03b1 \u03b5\u03c0\u03b7\u03c1\u03b5\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c4\u03cc\u03c3\u03bf \u03b1\u03c0\u03cc \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03b5\u03c1\u03b9\u03b2\u03b1\u03bb\u03bb\u03bf\u03bd\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2. \u0388\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ba\u03cd\u03c1\u03b9\u03bf\u03c5\u03c2 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b7 \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf MTHFR. \u03a3\u03ae\u03bc\u03b5\u03c1\u03b1, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03bb\u03ac \u03c7\u03b1\u03c1\u03b1\u03ba\u03c4\u03b7\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b4\u03cd\u03bf \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c4\u03bf \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf: \u03b7 C677T \u03ba\u03b1\u03b9 \u03b7 A1298C. \u0397 \u03b1\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf MTHFR \u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ae \u03c4\u03cc\u03c3\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7\u03c2 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae\u03c2 \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7\u03c2, \u03cc\u03c3\u03bf \u03ba\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf \u03c3\u03c7\u03b5\u03b4\u03b9\u03b1\u03c3\u03bc\u03cc \u03ba\u03b1\u03c4\u03ac\u03bb\u03bb\u03b7\u03bb\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae\u03c2 \u03b1\u03b3\u03c9\u03b3\u03ae\u03c2.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0388\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 \u0395\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03ae \u03c4\u03bf\u03c5 \u0391\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03a0\u03bb\u03b1\u03c3\u03bc\u03b9\u03bd\u03bf\u03b3\u03cc\u03bd\u03bf\u03c5 (PAI-1-4G\/5G)<\/strong><\/p>\n<p>\u039f \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 Plasminogen Activator Inhibitor-1 (PAI-1) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03b2\u03b1\u03c3\u03b9\u03ba\u03cc\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03b9\u03bd\u03bf\u03b4\u03ce\u03bb\u03c5\u03c3\u03b7\u03c2. \u038c\u03c4\u03b1\u03bd \u03c4\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 PAI-1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c8\u03b7\u03bb\u03ac \u03c4\u03cc\u03c4\u03b5 \u03b7 \u03b9\u03bd\u03bf\u03b4\u03ce\u03bb\u03c5\u03c3\u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03c4\u03b1\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03ac\u03bd\u03b5\u03b9 \u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03b1\u03c1\u03c4\u03b7\u03c1\u03b9\u03b1\u03ba\u03ae \u03ae \u03c6\u03bb\u03b5\u03b2\u03b9\u03ba\u03ae \u03b8\u03c1\u03cc\u03bc\u03b2\u03c9\u03c3\u03b7. \u0388\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03b3\u03bd\u03c9\u03c1\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b9\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf PAI-1, \u03b7 \u03bf\u03c0\u03bf\u03af\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03c9\u03c2 \u03b1\u03c0\u03bf\u03c4\u03ad\u03bb\u03b5\u03c3\u03bc\u03b1 \u03c4\u03b7\u03bd \u03cd\u03c0\u03b1\u03c1\u03be\u03b7 \u03b4\u03cd\u03bf \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5: 4G \u03ba\u03b1\u03b9 5G. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03c9\u03bd 4G\/4G \u03ba\u03b1\u03b9 4G\/5G \u03b3\u03bf\u03bd\u03bf\u03c4\u03cd\u03c0\u03c9\u03bd \u03c3\u03c4\u03bf\u03bd \u03c0\u03bb\u03b7\u03b8\u03c5\u03c3\u03bc\u03cc \u03b1\u03bd\u03ad\u03c1\u03c7\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf 28% \u03ba\u03b1\u03b9 48% \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03bf\u03b9\u03c7\u03b1 \u03ba\u03b1\u03b9 \u03bf\u03b9 \u03c3\u03c5\u03b3\u03ba\u03b5\u03ba\u03c1\u03b9\u03bc\u03ad\u03bd\u03bf\u03b9 \u03b3\u03bf\u03bd\u03cc\u03c4\u03c5\u03c0\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03ac\u03bc\u03b5\u03c3\u03b1 \u03bc\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 PAI-1 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1 \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c3\u03c5\u03bd\u03ad\u03c0\u03b5\u03b9\u03b1 \u03bc\u03b5 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03b9\u03b8\u03b1\u03bd\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b5\u03bc\u03c6\u03ac\u03bd\u03b9\u03c3\u03b7\u03c2 \u03b8\u03c1\u03bf\u03bc\u03b2\u03c9\u03c4\u03b9\u03ba\u03ce\u03bd \u03b5\u03c0\u03b5\u03b9\u03c3\u03bf\u03b4\u03af\u03c9\u03bd. \u0391\u03bd\u03c4\u03af\u03b8\u03b5\u03c4\u03b1 \u03b7 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 5G\/5G \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b1 \u03c7\u03b1\u03bc\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03bd\u03b5\u03c1\u03b3\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 PAI-1 \u03c3\u03c4\u03bf \u03c0\u03bb\u03ac\u03c3\u03bc\u03b1.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03b7\u03c2 \u0393\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u03af\u03bd\u03b7\u03c2 GPIa (GPIa -\u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7 C807T)<\/strong><\/p>\n<p>\u0397 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 GPIa, \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03ba\u03b1\u03b9 \u03c3\u03b1\u03bd \u03b9\u03bd\u03c4\u03b5\u03b3\u03ba\u03c1\u03af\u03bd\u03b7 \u03b12\u03b21, \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03bf\u03bb\u03bb\u03b1\u03b3\u03cc\u03bd\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1. \u039f \u03b4\u03b9\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 GPIa \u03c3\u03c4\u03bf \u03bd\u03bf\u03c5\u03ba\u03bb\u03b5\u03bf\u03c4\u03af\u03b4\u03b9\u03bf 807 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c3\u03c9\u03c3\u03c4\u03ae \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03bc\u03b5\u03c4\u03ac\u03bb\u03bb\u03b1\u03be\u03b7\u03c2 (\u03c4\u03bf\u03c5 \u03a4807 \u03b1\u03bb\u03bb\u03b7\u03bb\u03bf\u03bc\u03cc\u03c1\u03c6\u03bf\u03c5) \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bc\u03b5\u03b3\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b7 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b3\u03bb\u03c5\u03ba\u03bf\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd, \u03c3\u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c0\u03c1\u03bf\u03c3\u03ba\u03cc\u03bb\u03bb\u03b7\u03c3\u03ae \u03c4\u03bf\u03c5\u03c2 \u03c3\u03c4\u03bf \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03c0\u03b9\u03b8\u03ae\u03bb\u03b9\u03bf \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c4\u2019 \u03b5\u03c0\u03ad\u03ba\u03c4\u03b1\u03c3\u03b7  \u03c3\u03c4\u03b7\u03bd \u03b5\u03ba\u03b4\u03ae\u03bb\u03c9\u03c3\u03b7 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ae\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5.<\/p>\n<p>&nbsp;<\/p>\n<p><strong>\u0391\u03bd\u03af\u03c7\u03bd\u03b5\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 XIII - FACTOR XIII (34VAL\/LEU)<\/strong><\/p>\n<p><strong>\u00a0 \u00a0\u039f \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 XIII<\/strong> \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf  \u03c4\u03bf\u03c5 \u03c3\u03c5\u03c3\u03c4\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03ae\u03be\u03b7\u03c2, \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03b5\u03cd\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c3\u03c4\u03b1\u03b8\u03b5\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b4\u03b9\u03ba\u03c4\u03cd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b9\u03bd\u03ce\u03b4\u03bf\u03c5\u03c2. \u0397 \u03c0\u03b1\u03c1\u03bf\u03c5\u03c3\u03af\u03b1 \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03c5\u03bc\u03bf\u03c1\u03c6\u03b9\u03c3\u03bc\u03bf\u03cd Val34Leu \u03c3\u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 XIII \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03b8\u03b5\u03af \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03ba\u03b1\u03b8\u2019\u03b5\u03be\u03b9\u03bd \u03b1\u03c0\u03bf\u03b2\u03bf\u03bb\u03ad\u03c2.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Mutations detection in a number of genes that participate in blood clotting and they are genetic determinants for thrombosis. Such genes and their corresponding mutations are: Factor V Leiden (R506Q) Prothrombin (G20210A) MTHFR (C677T and A1298C) Factor XIII (V34L) PAI-1 (4G\/5G) GPI\u03b1 (C-807) A check is performed to detect major gene mutations: \u00a0 \u00a0 \u00a01)<\/p>","protected":false},"author":1,"featured_media":0,"parent":1056,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3140","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3140","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3140"}],"version-history":[{"count":3,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3140\/revisions"}],"predecessor-version":[{"id":4421,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3140\/revisions\/4421"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/1056"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3140"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}