{"id":3200,"date":"2021-07-09T12:07:48","date_gmt":"2021-07-09T12:07:48","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3200"},"modified":"2021-08-25T11:58:24","modified_gmt":"2021-08-25T11:58:24","slug":"gene_expression_of_cell_surface_receptors","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/services\/cancer\/prognosis_diagnosis\/gene_expression_of_cell_surface_receptors\/","title":{"rendered":"\u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 (\u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2) \u03b3\u03b9\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2"},"content":{"rendered":"<div id=\"pl-3200\"  class=\"panel-layout\" ><div id=\"pg-3200-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3200-0\" ><div id=\"pgc-3200-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3200-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3200-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">\u0393\u03bf\u03bd\u03b9\u03b4\u03b9\u03b1\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 (\u03c0\u03bf\u03c3\u03bf\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2) \u03b3\u03b9\u03b1 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>&nbsp;<\/p>\n<ul style=\"font-weight: 400;\">\n<li>\u0395GFR\/\u0395RBB1<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u039f \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 (EGFR),\u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2  \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2, \u03c0\u03bf\u03c5 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c5\u03c0\u03b5\u03c1\u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b7-\u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 (NSCLC). \u0391\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c0\u03b1\u03af\u03b6\u03bf\u03c5\u03bd  \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5-\u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03b9\u03c9\u03bc\u03ad\u03bd\u03bf\u03c5 EGFR \u03c3\u03c4\u03b7 \u03c6\u03c9\u03c3\u03c6\u03bf\u03c1\u03c5\u03bb\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03ce\u03bd \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc, \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae, \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7, \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7\u03c2. \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03be\u03b1\u03c1\u03c4\u03ac\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b9\u03c3\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c5\u03c0\u03bf\u03c4\u03cd\u03c0\u03bf\u03c5\u03c2, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03c0\u03b9\u03bf \u03c3\u03c5\u03c7\u03bd\u03ac \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03c0\u03bb\u03b1\u03ba\u03ce\u03b4\u03bf\u03c5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c5\u03c7\u03bd\u03ac \u03c3\u03b5 \u03b1\u03b4\u03b5\u03bd\u03bf\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03b5\u03b3\u03ac\u03bb\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0388\u03bd\u03b1 \u03c0\u03bf\u03bb\u03cd \u03c0\u03b9\u03bf \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03b6\u03ae\u03c4\u03b7\u03bc\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 NSCLC \u03b5\u03af\u03bd\u03b1\u03b9 \u03c4\u03bf \u03ba\u03b1\u03c4\u03ac \u03c0\u03cc\u03c3\u03bf\u03bd \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c7\u03ad\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03b7\u03c2 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 EGFR \u03ba\u03b1\u03b9 \u03cc\u03c6\u03b5\u03bb\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03bc\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 EGFR. \u0391\u03c5\u03c4\u03cc \u03af\u03c3\u03c9\u03c2 \u03b4\u03c5\u03c3\u03b1\u03bd\u03b1\u03c3\u03c7\u03b5\u03c4\u03b5\u03af \u03c4\u03bf\u03c5\u03c2  \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03b1\u03c1\u03bd\u03b7\u03c4\u03b9\u03ba\u03ae \u03ae \u03c7\u03b1\u03bc\u03b7\u03bb\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 EGFR \u03c0\u03bf\u03c5 \u03b8\u03b1 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03c3\u03b1\u03bd \u03bd\u03b1 \u03c9\u03c6\u03b5\u03bb\u03b7\u03b8\u03bf\u03cd\u03bd \u03b1\u03c0\u03cc \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 EGFR, \u03ba\u03b1\u03b8\u03ce\u03c2 \u03bf\u03b9 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03b1\u03c6\u03bf\u03c1\u03bf\u03cd\u03bd \u03c4\u03bf\u03bd \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 EGFR \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03af\u03bf\u03c5\u03bd \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03c7\u03c9\u03c1\u03af\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ca\u03bd\u03b9\u03ba\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 EGFR. \u0394\u03cd\u03bf \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 EGFR \u03c4\u03bf gefitinib (Iressa) \u03ba\u03b1\u03b9 \u03c4\u03bf erlotinib (Tarceva), \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b3\u03ba\u03c1\u03b9\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03c7\u03c1\u03ae\u03c3\u03b7 \u03c9\u03c2 \u03b4\u03b5\u03cd\u03c4\u03b5\u03c1\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03ae  \u03c4\u03c1\u03af\u03c4\u03b7\u03c2 \u03b3\u03c1\u03b1\u03bc\u03bc\u03ae\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c3\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf NSCLC.<\/p>\n<p style=\"font-weight: 400;\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2104566\/\">http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2104566\/<\/a><\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>HER2\/ERBB2<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u03a4\u03bf HER2 (\u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03bf\u03c2 \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03cc\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Protein&amp;usg=ALkJrhhIQ9Pi5ZDo3XaDYXdsAhfLm48Xzg\">\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a>\u00a0\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf ERBB2\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gene&amp;usg=ALkJrhiwGorlgjPHCNRDhxl_x8dFFEaV7A\">\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>\u00a0.\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gene_duplication&amp;usg=ALkJrhiquZvvm5brvxthF2C_z-hHGCCOig\">\u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7<\/a>\u00a0\u03ae \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c4\u03cd\u03c0\u03c9\u03bd \u03c4\u03bf\u03c5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Breast_cancer&amp;usg=ALkJrhjfGj4glBYd7mwwesnX5uI9y8Q50A\">\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd<\/a>\u00a0\u03ba\u03b1\u03b9 \u03c4\u03b1 \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03b1 \u03c7\u03c1\u03cc\u03bd\u03b9\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b5\u03be\u03b5\u03bb\u03b9\u03c7\u03b8\u03b5\u03af \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Biomarker_(medicine)&amp;usg=ALkJrhiH_jHSnNimQRIUN91dOHX_6xrD9g\">\u03b2\u03b9\u03bf\u03b4\u03b5\u03af\u03ba\u03c4\u03b7<\/a>\u00a0\u03ba\u03b1\u03b9 \u03c3\u03c4\u03cc\u03c7\u03bf \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1. \u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03ae \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 ERBB2 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03b5\u03c1\u03af\u03c0\u03bf\u03c5 30% \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd. \u0395\u03af\u03bd\u03b1\u03b9 \u03c3\u03c4\u03b5\u03bd\u03ac \u03c3\u03c5\u03bd\u03b4\u03b5\u03b4\u03b5\u03bc\u03ad\u03bd\u03bf \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03c4\u03b7\u03c2 \u03bd\u03cc\u03c3\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03c7\u03b5\u03b9\u03c1\u03cc\u03c4\u03b5\u03c1\u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7. \u03a5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03cc\u03c4\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c9\u03bf\u03b8\u03ae\u03ba\u03b5\u03c2, \u03c3\u03c4\u03bf \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03b9 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03b5\u03c0\u03b9\u03b8\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03b7\u03c2 \u03bc\u03ae\u03c4\u03c1\u03b1\u03c2. \u039f\u03b9 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b5\u03c2 HER2 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03c0\u03bf\u03b4\u03b5\u03b9\u03c7\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03bf\u03bc\u03ac\u03b4\u03b5\u03c2 \u03c3\u03c4\u03b9\u03c2 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b5\u03c2 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03bf\u03c5\u03bd \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf  \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u03a4\u03bf HER2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dher2%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Monoclonal_antibodies&amp;usg=ALkJrhidAwIbShOpCWryhP5obnrWJpd15g\">\u03bc\u03bf\u03bd\u03bf\u03ba\u03bb\u03c9\u03bd\u03b9\u03ba\u03bf\u03cd \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03bf\u03c2<\/a>\u00a0Herceptin \u03c4\u03bf \u03bf\u03c0\u03bf\u03af\u03bf \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03cc \u03bc\u03cc\u03bd\u03bf \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c0\u03bf\u03c5 \u03c4\u03bf HER2 \u03c5\u03c0\u03b5\u03c1\u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9. \u039f \u03ad\u03bb\u03b5\u03b3\u03c7\u03bf\u03c2 \u03c4\u03bf\u03c5 HER2 \u03b3\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b7\u03b8\u03b5\u03af \u03b7 \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03bd\u03b1 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03b8\u03b5\u03af \u03b7 \u03ba\u03b1\u03c4\u03b1\u03bb\u03bb\u03b7\u03bb\u03cc\u03c4\u03b7\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2 \u03bc\u03b5 Herceptin. \u03a4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03bc\u03ad\u03c7\u03c1\u03b9 \u03c4\u03ce\u03c1\u03b1 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b4\u03b5\u03af\u03be\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03b1\u03bb\u03bb\u03b1\u03b3\u03ad\u03c2 \u03c4\u03b7\u03c2 \u03c3\u03c5\u03b3\u03ba\u03ad\u03bd\u03c4\u03c1\u03c9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03bf\u03bd \u03bf\u03c1\u03cc \u03c4\u03bf\u03c5 HER2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03c7\u03c1\u03ae\u03c3\u03b9\u03bc\u03b5\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03c0\u03c1\u03cc\u03b2\u03bb\u03b5\u03c8\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 Herceptin.<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>ERBB3<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u03a4\u03bf ERBB3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03bb\u03bf\u03c2 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03c4\u03c9\u03bd EGF \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd. \u03a3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 ERBB3 \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03b7\u03bd \u03b5\u03c1\u03b5\u03b3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 (HRG) \u03ba\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c0\u03c1\u03bf\u03c3\u03b4\u03ad\u03c4\u03b5\u03c2 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 (EGFR) \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03b2\u03b7\u03c4\u03b1\u03c3\u03b5\u03bb\u03bf\u03c5\u03bb\u03af\u03bd\u03b7 (BTC). \u039f ERBB3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03c1\u03af\u03c3\u03b9\u03bc\u03bf\u03c2 \u03bc\u03b5\u03c3\u03bf\u03bb\u03b1\u03b2\u03b7\u03c4\u03ae\u03c2  \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5  PI3K\/AKT \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03b9\u03b8\u03b1\u03bd\u03ce\u03c2 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03b7\u03c2 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03ce\u03bd \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc, \u03c4\u03b7 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0397 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03cc\u03c4\u03b7\u03c3\u03b7 \u03bc\u03ad\u03c3\u03c9 \u03c4\u03bf\u03c5 ERBB3 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03ba\u03cd\u03c1\u03b9\u03bf\u03c2 \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03cc\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03bf\u03c0\u03bf\u03af\u03bf \u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c0\u03bf\u03ba\u03c4\u03bf\u03cd\u03bd \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae \u03c3\u03b5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2 (\u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5 EGFR \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 HER2), \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2, \u03ba\u03b1\u03b9 \u03b5\u03bd\u03b4\u03b5\u03c7\u03bf\u03bc\u03ad\u03bd\u03c9\u03c2 \u03c4\u03b7\u03bd \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u0395\u03bd\u03af\u03c3\u03c7\u03c5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5 \u03b1\u03c5\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \/ \u03ae \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2  \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03c3\u03b5 \u03c0\u03bf\u03bb\u03c5\u03ac\u03c1\u03b9\u03b8\u03bc\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03c4\u03b7\u03c2 \u03ba\u03cd\u03c3\u03c4\u03b7\u03c2, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd.<\/p>\n<p style=\"font-weight: 400;\">Schoeberl B, Faber AC, Li D, et al. Cancer Res. 2010;70:2485-2494.<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>C-\u039c\u0395\u03a4<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u03a4\u03bf c-Met \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dmet%2Bgene%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Proto-oncogene&amp;usg=ALkJrhi_SDgTqBbzFYjov6RQP5kUocrCMw\">\u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>\u00a0\u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af  \u03bc\u03af\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dmet%2Bgene%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Protein&amp;usg=ALkJrhiM1PExEpoz4akEhI4H8bVJcvCaeA\">\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a>\u00a0\u03b3\u03bd\u03c9\u03c3\u03c4\u03ae \u03c9\u03c2 \u03b7\u03c0\u03b1\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 (HGFR). \u039c\u03b7 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7  \u03c4\u03bf\u03c5 MET \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03ba\u03b1\u03ba\u03ae \u03c0\u03c1\u03cc\u03b3\u03bd\u03c9\u03c3\u03b7, \u03cc\u03c0\u03bf\u03c5 \u03b1\u03bd\u03c9\u03bc\u03ac\u03bb\u03c9\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc \u039c\u0395\u03a4 \u03b4\u03b9\u03b5\u03b3\u03b5\u03af\u03c1\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5, \u03c4\u03bf \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03cc \u03bd\u03ad\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c6\u03cc\u03c1\u03c9\u03bd \u03b1\u03b3\u03b3\u03b5\u03af\u03c9\u03bd (<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dmet%2Bgene%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Angiogenesis&amp;usg=ALkJrhglIh6vuDYaD3YVUx06WajFXqKvTA\">\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2<\/a>) \u03c0\u03bf\u03c5 \u03b5\u03c6\u03bf\u03b4\u03b9\u03ac\u03b6\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03cc\u03b3\u03ba\u03bf \u03bc\u03b5 \u03b8\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03ac \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ac, \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03c0\u03bb\u03c9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c3\u03b5 \u03ac\u03bb\u03bb\u03b1 \u03cc\u03c1\u03b3\u03b1\u03bd\u03b1 (<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dmet%2Bgene%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Metastasis&amp;usg=ALkJrhgClExx0iu0S9dH7Z7zBLT5gfSyOA\">\u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7<\/a>. \u03a4\u03bf \u039c\u0395\u03a4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03bf\u03c1\u03c1\u03c5\u03b8\u03bc\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03ba\u03b1\u03ba\u03bf\u03b7\u03b8\u03b5\u03b9\u03ce\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bd\u03b5\u03c6\u03c1\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2, \u03c4\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bc\u03ac\u03c7\u03bf\u03c5, \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03b5\u03b3\u03ba\u03b5\u03c6\u03ac\u03bb\u03bf\u03c5. \u039b\u03cc\u03b3\u03c9 \u03c4\u03bf\u03c5 \u03bc\u03bf\u03bd\u03b1\u03b4\u03b9\u03ba\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c1\u03cc\u03bb\u03bf\u03c5 \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03c4\u03bf \u039c\u0395\u03a4 \u03ad\u03c7\u03b5\u03b9 \u03b8\u03b5\u03c9\u03c1\u03b7\u03b8\u03b5\u03af \u03ad\u03bd\u03b1\u03c2 \u03b5\u03bb\u03ba\u03c5\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5. \u039a\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03c4\u03b5\u03bb\u03b5\u03c5\u03c4\u03b1\u03af\u03c9\u03bd \u03c4\u03b5\u03c3\u03c3\u03ac\u03c1\u03c9\u03bd \u03b5\u03c4\u03ce\u03bd, \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b1\u03c0\u03cc  10 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03c0\u03c4\u03c5\u03c7\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03c4\u03bf\u03b4\u03bf\u03c4\u03b9\u03ba\u03bf\u03cd  \u03bc\u03bf\u03bd\u03bf\u03c0\u03b1\u03c4\u03b9\u03bf\u03cd \u03c4\u03bf\u03c5 \u039c\u0395\u03a4 \u03bc\u03ad\u03c3\u03c9 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03b7\u03c7\u03b1\u03bd\u03b9\u03c3\u03bc\u03ce\u03bd \u03ad\u03c7\u03bf\u03c5\u03bd \u03b5\u03b9\u03c3\u03b1\u03c7\u03b8\u03b5\u03af \u03c3\u03c4\u03b7\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ae. \u0397 \u03c0\u03bb\u03b5\u03b9\u03bf\u03c8\u03b7\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03c9\u03bd \u03c4\u03bf\u03c5 \u039c\u0395\u03a4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03ba\u03cc\u03bc\u03b1 \u03c3\u03b5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ad\u03c2 \u03a6\u03ac\u03c3\u03b7\u03c2 \u0399 \u03ba\u03b1\u03b9 \u0399\u0399, \u03b1\u03bb\u03bb\u03ac \u03c4\u03bf\u03c5\u03bb\u03ac\u03c7\u03b9\u03c3\u03c4\u03bf\u03bd \u03c4\u03c1\u03b5\u03b9\u03c2 \u03b5\u03bd\u03ce\u03c3\u03b5\u03b9\u03c2 tivantinib, onartuzumab, \u03ba\u03b1\u03b9 cabozantinib, \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b5\u03c2 \u03c6\u03ac\u03c3\u03b7\u03c2 \u0399\u0399\u0399 \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bc\u03b1 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2. \u0398\u03b1 \u03c0\u03c1\u03ad\u03c0\u03b5\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c3\u03b7\u03bc\u03b5\u03b9\u03c9\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c4\u03bf \u039c\u0395\u03a4 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03cc\u03c7\u03b9 \u03bc\u03cc\u03bd\u03bf \u03c3\u03c4\u03b1 \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03bf\u03c3\u03c4\u03b5\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 (\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c7\u03b7\u03bc\u03b1\u03c4\u03b9\u03c3\u03bc\u03bf\u03cd \u03bf\u03c3\u03c4\u03ce\u03bd) \u03ba\u03b1\u03b9 \u03bf\u03c3\u03c4\u03b5\u03bf\u03ba\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 (\u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03b1\u03c6\u03b1\u03af\u03c1\u03b5\u03c3\u03b7\u03c2 \u03bf\u03c3\u03c4\u03ce\u03bd). \u03a4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03c4\u03bf\u03c5 \u039c\u0395\u03a4 \u03b1\u03c6\u03cd\u03c3\u03b9\u03ba\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd \u03c0\u03b9\u03bf \u03ba\u03bf\u03b9\u03bd\u03ce\u03bd \u03b5\u03c0\u03b9\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ce\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03c9\u03bd \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1, \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2, \u03c4\u03bf\u03c5 \u03ae\u03c0\u03b1\u03c4\u03bf\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd. \u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 \u039c\u0395\u03a4 \u03c0\u03b1\u03c1\u03b1\u03bc\u03ad\u03bd\u03bf\u03c5\u03bd \u03bc\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03ac \u03c5\u03c0\u03bf\u03c3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03c4\u03ac\u03be\u03b7 \u03b5\u03bd\u03ce\u03c3\u03b5\u03c9\u03bd \u03b3\u03b9\u03b1 \u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5.<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>RET<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>C-KIT<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u03a4\u03bf \u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf c-Kit \u03ae \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2- \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2  \u03ae CD117, \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Protein&amp;usg=ALkJrhjZuU3Usgwgs9VaxpQXX_uFPwD5pw\">\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a>\u00a0\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u039a\u0399\u03a4\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gene&amp;usg=ALkJrhjsieImt1ZEYjiqZWr_rFvPCQPbWA\">\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>. \u03a4\u03bf CD117 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2  \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03b5\u03c0\u03b9\u03c6\u03b1\u03bd\u03b5\u03af\u03b1\u03c2 \u03c0\u03bf\u03c5 \u03c7\u03c1\u03b7\u03c3\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03c4\u03bf\u03bd \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03b9\u03c3\u03bc\u03cc \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03cd\u03c0\u03c9\u03bd\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Hematopoietic&amp;usg=ALkJrhhaIry1MGcSw_hSPIDcpdfU7xdnGQ\">\u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd<\/a>\u00a0\u03c0\u03c1\u03bf\u03b3\u03cc\u03bd\u03c9\u03bd \u03c3\u03c4\u03bf\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Bone_marrow&amp;usg=ALkJrhjLPbNGKp1vC96CbnVVzXkUBo7TAw\">\u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd<\/a>.\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Altered&amp;usg=ALkJrhj0F4QPHl0vlxyQ2E8JKVd_99ke-g\">\u0391\u03bb\u03bb\u03bf\u03b9\u03c9\u03bc\u03ad\u03bd\u03b5\u03c2<\/a>\u00a0\u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03b1\u03c5\u03c4\u03bf\u03cd \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c3\u03c5\u03bd\u03b4\u03ad\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Cancer&amp;usg=ALkJrhiNaUzts2cyvIu0uqEtOhB9NMeG-A\">\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/a>\u0397 \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gastrointestinal_stromal_tumor&amp;usg=ALkJrhheBeD0clxC-pJCP1QFMbytwZkvqg\">\u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2<\/a>\u00a0\u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b1 \u03b2\u03b1\u03c3\u03b5\u03cc\u03c6\u03b9\u03bb\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03bf\u03c5, \u03bc\u03b5\u03bb\u03ac\u03bd\u03c9\u03bc\u03b1, \u03c4\u03b7\u03bd \u03bf\u03be\u03b5\u03af\u03b1 \u03bc\u03c5\u03b5\u03bb\u03bf\u03b5\u03b9\u03b4\u03ae \u03bb\u03b5\u03c5\u03c7\u03b1\u03b9\u03bc\u03af\u03b1, \u03b5\u03bd\u03ce \u03bf\u03b9 \u03b1\u03b4\u03c1\u03b1\u03bd\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b5\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7 \u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ae \u03b1\u03bd\u03c9\u03bc\u03b1\u03bb\u03af\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Piebaldism&amp;usg=ALkJrhjS5yEkt4VrQ4PRS1CXQYR0zmAaAQ\">piebaldism<\/a>\u00a0. \u03a4\u03bf CD117 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dc-kit%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Proto-oncogene&amp;usg=ALkJrhjub28DC377hKYhA3Wir1WILtr7Uw\">\u03c0\u03c1\u03c9\u03c4\u03bf-\u03bf\u03b3\u03ba\u03bf\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>\u00a0, \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03c5\u03c0\u03b5\u03c1\u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03ae \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03b1\u03c5\u03c4\u03ae\u03c2 \u03c4\u03b7\u03c2 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03bf\u03c5\u03bd \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf. \u03a4\u03bf c-kit \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03ad\u03c7\u03b5\u03b9 \u03c3\u03c5\u03bd\u03b4\u03b5\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03c0\u03c1\u03bf\u03ce\u03b8\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae\u03c2 \u03bc\u03b5\u03c4\u03b1\u03bd\u03ac\u03c3\u03c4\u03b5\u03c5\u03c3\u03b7\u03c2, \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03ba\u03b1\u03b9\/\u03ae \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c4\u03c9\u03bd \u03bc\u03b5\u03bb\u03b1\u03bd\u03bf\u03b2\u03bb\u03b1\u03c3\u03c4\u03ce\u03bd, \u03c4\u03c9\u03bd \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03c1\u03bf\u03b3\u03bf\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03b1\u03c1\u03c7\u03ad\u03b3\u03bf\u03bd\u03c9\u03bd \u03b3\u03b5\u03bd\u03bd\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u0391\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03b1\u03bd\u03b1\u03c6\u03bf\u03c1\u03ad\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03c0\u03c1\u03bf\u03c4\u03b5\u03af\u03bd\u03b5\u03b9 \u03ad\u03bd\u03b1 \u03c1\u03cc\u03bb\u03bf \u03b3\u03b9\u03b1 \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf c-kit \u03c3\u03c4\u03b7\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7. \u03a4\u03bf STI571 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03bc\u03b9\u03ba\u03c1\u03cc \u03bc\u03cc\u03c1\u03b9\u03bf \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03b5\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03c4\u03b7\u03bd \u03b5\u03bd\u03b6\u03c5\u03bc\u03b1\u03c4\u03b9\u03ba\u03ae \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1 \u03b4\u03b9\u03b1\u03c6\u03cc\u03c1\u03c9\u03bd \u03ba\u03b9\u03bd\u03b1\u03c3\u03ce\u03bd \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2, \u03cc\u03c0\u03c9\u03c2 \u03bf \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03bc\u03b5 \u03b4\u03c1\u03ac\u03c3\u03b7 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2, \u03ad\u03bd\u03b1 \u03c0\u03c1\u03bf\u03ca\u03cc\u03bd \u03c4\u03bf\u03c5 c-kit \u03b3\u03bf\u03bd\u03b9\u03b4\u03af\u03bf\u03c5. \u039f \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03cc\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c4\u03b7\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ba\u03c5\u03c4\u03bf\u03ba\u03af\u03bd\u03b7\u03c2 \u03b2\u03bb\u03b1\u03c3\u03c4\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd (SFC), \u03c0\u03bf\u03c5 \u03bf\u03bd\u03bf\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b9\u03c3\u03c4\u03b9\u03bf\u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03ae \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 Steel. \u039c\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 c-\u039a\u0399\u03a4 \u03c0\u03bf\u03c5 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03bf\u03cd\u03bd \u03c3\u03c5\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ae \u03b5\u03bd\u03b5\u03c1\u03b3\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1\u03c2 \u03c4\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 c-\u039a\u0399\u03a4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b9\u03c7\u03bd\u03b5\u03cd\u03c3\u03b9\u03bc\u03b5\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03bf\u03c5\u03c2 \u03b3\u03b1\u03c3\u03c4\u03c1\u03b5\u03bd\u03c4\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03cd\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5\u03c2 (GISTs).<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>PDGFR\u03b1<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u039f\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Receptor_tyrosine_kinase&amp;usg=ALkJrhicblJL_dmeDIxNfBN2IG40qJMSZg\">\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2<\/a>\u00a0\u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b2\u03c1\u03af\u03c3\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03ba\u03b1\u03b9  \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03ad\u03bb\u03b7 \u03c4\u03b7\u03c2 \u03bf\u03b9\u03ba\u03bf\u03b3\u03ad\u03bd\u03b5\u03b9\u03b1\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03ce\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Platelet-derived_growth_factor&amp;usg=ALkJrhhPi9kYq56GJGvNh6S0FQb8F_nYRw\">\u03c0\u03c1\u03bf\u03ad\u03c1\u03c7\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03ac\u03bb\u03b9\u03b1<\/a>\u00a0\u039f\u03b9 PDGF \u03c5\u03c0\u03bf\u03bc\u03bf\u03bd\u03ac\u03b4\u03b5\u03c2\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/PDGFA&amp;usg=ALkJrhjAL9dxlkJsjM0vCdkiaYI1P59_CA\">-A<\/a>\u00a0\u03ba\u03b1\u03b9\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/PDGFB&amp;usg=ALkJrhiKXfJ6-utUL1u4-Lu5TdioG_yacg\">-B<\/a>\u00a0\u03b5\u03af\u03bd\u03b1\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03bf\u03b9 \u03b5\u03bb\u03ad\u03b3\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Cell_proliferation&amp;usg=ALkJrhiDlcl00ppvJ6LGPFyaiaxDv_1FTg\">\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03cc \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc<\/a>,\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Cellular_differentiation&amp;usg=ALkJrhiiPOcHew4s_o2aX6tQHaSF5pJf9A\">\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7<\/a>,\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Cell_growth&amp;usg=ALkJrhj2mIz3Ucp1XVayAm1ZVCY_dbRheg\">\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ae \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7<\/a>,\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Morphogenesis&amp;usg=ALkJrhhkH-06W1dcYKKTsDakkaj-LmB-7A\">development<\/a>\u00a0\u03b1\u03b9 \u03c0\u03bf\u03bb\u03bb\u03ad\u03c2 \u03b1\u03c3\u03b8\u03ad\u03bd\u03b5\u03b9\u03b5\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Cancer&amp;usg=ALkJrhiVD-v8uZCm5axzRGJai8AP_S_AMg\">\u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5<\/a>\u039f \u03ac\u03bb\u03c6\u03b1 \u03c4\u03cd\u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03b1\u03b9\u03bc\u03bf\u03c0\u03b5\u03c4\u03b1\u03bb\u03af\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Protein&amp;usg=ALkJrhh5TMDiOLZVJJbVBWT2_-anOEy6yg\">\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a>\u00a0\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf PDGFRa\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dpdgfra%2Bgene%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gene&amp;usg=ALkJrhiRdwTxJR4iHeJu20xt1zY3gCCMVA\">\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>\u00a0\u03a5\u03c0\u03b5\u03c1\u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03c5\u03c0\u03bf\u03c3\u03cd\u03bd\u03bf\u03bb\u03bf \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ce\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bf \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c4\u03c9\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd  \u03c0\u03bf\u03c5 \u03b1\u03bd\u03b1\u03c3\u03c4\u03ad\u03bb\u03bb\u03bf\u03c5\u03bd \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03af\u03b1, \u03cc\u03c0\u03c9\u03c2 \u03c4\u03bf imatinib mesylate (Gleevec).<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>IGF1R<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u039f \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 \u03b9\u03bd\u03c3\u03bf\u03c5\u03bb\u03af\u03bd\u03b7\u03c2 IGFR1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03c6\u03ac\u03bd\u03b5\u03b9\u03b1 \u03c4\u03c9\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd. \u03a0\u03b1\u03af\u03b6\u03b5\u03b9  \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7, \u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc, \u03c4\u03b7\u03bd \u03b1\u03c0\u03cc\u03c0\u03c4\u03c9\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b5\u03b9\u03c3\u03b2\u03bf\u03bb\u03ae \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b5\u03be\u03b1\u03ba\u03bf\u03bb\u03bf\u03c5\u03b8\u03b5\u03af \u03bd\u03b1 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03b2\u03bf\u03bb\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b5\u03bd\u03ae\u03bb\u03b9\u03ba\u03b5\u03c2 , \u03c0\u03c1\u03ac\u03b3\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c3\u03b7\u03bc\u03b1\u03af\u03bd\u03b5\u03b9 \u03cc\u03c4\u03b9 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03c1\u03bf\u03ba\u03b1\u03bb\u03ad\u03c3\u03b5\u03b9 \u03c5\u03c0\u03b5\u03c1\u03c4\u03c1\u03bf\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03c3\u03ba\u03b5\u03bb\u03b5\u03c4\u03b9\u03ba\u03ce\u03bd \u03bc\u03c5\u03ce\u03bd \u03ba\u03b1\u03b9 \u03ac\u03bb\u03bb\u03c9\u03bd \u03b9\u03ce\u03bd \u03c3\u03c4\u03cc\u03c7\u03c9\u03bd. \u039f IGFR1 \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7, \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c7\u03ad\u03bf\u03c2 \u03b5\u03bd\u03c4\u03ad\u03c1\u03bf\u03c5, \u03c4\u03bf\u03c5 \u03c0\u03b1\u03b3\u03ba\u03c1\u03ad\u03b1\u03c4\u03bf\u03c2, \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03b8\u03c5\u03c1\u03b5\u03bf\u03b5\u03b9\u03b4\u03bf\u03cd\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1. \u0388\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03c6\u03b5\u03c1\u03b8\u03b5\u03af \u03cc\u03c4\u03b9 \u03c4\u03bf \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03bf \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03ae\u03c2 \u03c4\u03bf\u03c5 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ad\u03c2 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b5\u03c2. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03ba\u03ac\u03c4\u03c9 \u03c1\u03cd\u03b8\u03bc\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 IGF1R \u03c3\u03c7\u03b5\u03c4\u03af\u03c3\u03c4\u03b7\u03ba\u03b5 \u03bc\u03b5 \u03bc\u03b5\u03b9\u03c9\u03bc\u03ad\u03bd\u03b7 \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03cc\u03b3\u03ba\u03c9\u03bd \u03c3\u03b5 \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03b1 \u03bc\u03bf\u03bd\u03c4\u03ad\u03bb\u03b1 \u03be\u03b5\u03bd\u03bf\u03bc\u03bf\u03c3\u03c7\u03b5\u03cd\u03bc\u03b1\u03c4\u03bf\u03c2 \u03cc\u03b3\u03ba\u03bf\u03c5. \u039b\u03cc\u03b3\u03c9 \u03c4\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03c3\u03af\u03b1\u03c2 \u03c4\u03bf\u03c5 IGF1R \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03c0\u03bf\u03bb\u03bb\u03bf\u03af \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03bf\u03af \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b1\u03bd\u03c4\u03b9\u03c3\u03ce\u03bc\u03b1\u03c4\u03b1 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b1\u03bd\u03b1\u03c0\u03c4\u03c5\u03c7\u03b8\u03b5\u03af \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03c3\u03bf\u03c5\u03bd\/\u03b1\u03bd\u03b1\u03c3\u03c4\u03b5\u03af\u03bb\u03bf\u03c5\u03bd \u03c4\u03bf  IGF1R \u03ba\u03b1\u03b9 \u03b1\u03c1\u03ba\u03b5\u03c4\u03bf\u03af \u03b1\u03c0\u03cc \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b5\u03c0\u03af \u03c4\u03bf\u03c5 \u03c0\u03b1\u03c1\u03cc\u03bd\u03c4\u03bf\u03c2 \u03c3\u03b5 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b5\u03c2. \u03a3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03b5\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c0\u03c4\u03ce\u03c3\u03b5\u03b9\u03c2 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b1\u03c0\u03bf\u03c0\u03c4\u03c9\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c4\u03bf\u03c5 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03bf\u03c5\u03bd \u03c3\u03c4\u03b1 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03bd\u03b1 \u03b1\u03bd\u03c4\u03b9\u03c3\u03c4\u03ad\u03ba\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c4\u03c9\u03bd \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ce\u03bd \u03c6\u03b1\u03c1\u03bc\u03ac\u03ba\u03c9\u03bd \u03ae \u03c4\u03b7\u03c2 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.  \u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c4\u03bf\u03c5 IGFR1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7\u03bd \u03c0\u03bb\u03b5\u03b9\u03bf\u03c8\u03b7\u03c6\u03af\u03b1 \u03c4\u03c9\u03bd \u03c0\u03c1\u03c9\u03c4\u03bf\u03c0\u03b1\u03b8\u03ce\u03bd \u03ba\u03b1\u03b9 \u03bc\u03b5\u03c4\u03b1\u03c3\u03c4\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd \u03c4\u03bf\u03c5 \u03c0\u03c1\u03bf\u03c3\u03c4\u03ac\u03c4\u03b7 \u03b1\u03c3\u03b8\u03b5\u03bd\u03ce\u03bd.<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>VEGFR2<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u039f\u03b9 VEGF\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?depth=1&amp;hl=el&amp;prev=\/search%3Fq%3Dvegf%2Breceptor%26hl%3Del%26rlz%3D1R2NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Biochemical_receptors&amp;usg=ALkJrhgJ4VFg-yKxmenMN5kJOz3eyeGdQQ\">\u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2<\/a>\u00a0\u03b5\u03af\u03bd\u03b1\u03b9 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?depth=1&amp;hl=el&amp;prev=\/search%3Fq%3Dvegf%2Breceptor%26hl%3Del%26rlz%3D1R2NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Vascular_endothelial_growth_factor&amp;usg=ALkJrhhAx-pL_zxkrCp4l_4b_ef6aG7GiQ\">\u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03bf\u03cd \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03bf\u03cd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1<\/a>\u00a0(VEGF). \u03a5\u03c0\u03ac\u03c1\u03c7\u03bf\u03c5\u03bd \u03c4\u03c1\u03b5\u03b9\u03c2 \u03ba\u03cd\u03c1\u03b9\u03b5\u03c2 \u03c5\u03c0\u03bf\u03ba\u03b1\u03c4\u03b7\u03b3\u03bf\u03c1\u03af\u03b5\u03c2 \u03c4\u03bf\u03c5 VEGFR 1, 2 \u03ba\u03b1\u03b9 3. \u039a\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03b9 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03cc \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03cc \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03cc \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 (VEGF), \u03ae \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5. \u0391\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03b7 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 VEGF \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03b1\u03c5\u03be\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03af\u03bd\u03b4\u03c5\u03bd\u03bf \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae\u03c2. \u039c\u03bf\u03bb\u03bf\u03bd\u03cc\u03c4\u03b9 \u03bf\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03b5\u03bd\u03b5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03b5\u03c0\u03b9\u03b4\u03c1\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03c9\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03c5\u03bd \u03b5\u03bd\u03ac\u03bd\u03c4\u03b9\u03b1 \u03c3\u03c4\u03bf\u03bd VEGF \u03ad\u03c7\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd\u03b9\u03c3\u03c4\u03b5\u03af \u03c3\u03c4\u03bf\u03bd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf, \u03cc\u03b3\u03ba\u03bf\u03b9 \u03c0\u03bf\u03c5 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03bf\u03c5\u03bd \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd VEGF \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03c0\u03bf\u03c1\u03bf\u03cd\u03bd \u03bd\u03b1 \u03c3\u03c5\u03bc\u03bc\u03b5\u03c4\u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b5\u03af\u03c2 \/\u03c0\u03b1\u03c1\u03b1\u03ba\u03c1\u03b9\u03bd\u03b5\u03af\u03c2 \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5\u03c2 \u03b1\u03bd\u03ac\u03b4\u03c1\u03b1\u03c3\u03b7\u03c2, \u03ba\u03b1\u03b9 \u03c4\u03b1 \u03b5\u03b9\u03b4\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03c9\u03bd \u03b1\u03bd\u03c4\u03b9-VEGF \u03c0\u03b1\u03c1\u03b1\u03b3\u03cc\u03bd\u03c4\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03bf\u03cd\u03c2 \u03c4\u03bf\u03c5\u03c2 \u03b1\u03c5\u03c4\u03bf\u03ba\u03c1\u03b9\u03bd\u03b5\u03af\u03c2 \u03b2\u03c1\u03cc\u03c7\u03bf\u03c5\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03b8\u03bf\u03cd\u03bd in vitro , \u03cc\u03c0\u03bf\u03c5 \u03b7 \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03b4\u03b5\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03b8\u03ad\u03bc\u03b1. \u03a4\u03bf HER2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 VEGF \u03c3\u03b5 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03b9\u03bd\u03b5\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd, \u03ba\u03b1\u03b9 \u03c4\u03b1 VEGF \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c7\u03b5\u03c4\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03bc\u03b5 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 HER2 \u03c3\u03b5 \u03c0\u03c1\u03c9\u03c4\u03bf\u03b3\u03b5\u03bd\u03b5\u03af\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd. \u03a4\u03bf EGFR \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03b6\u03b5\u03b9 \u03c0\u03c1\u03bf\u03c2 \u03c4\u03b1 \u03b5\u03c0\u03ac\u03bd\u03c9 \u03c4\u03b7\u03bd \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 VEGF \u03c3\u03b5 \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ad\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2, \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae \u03c4\u03b7\u03c2 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c4\u03bf\u03c5 EGFR \u03bc\u03b5\u03b9\u03ce\u03bd\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 VEGF \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03b3\u03b3\u03b5\u03b9\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 in \u03bd\u03af\u03bd\u03bf. \u0394\u03b5\u03b4\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03cc\u03c4\u03b9 \u03c4\u03bf HER2 \u03ba\u03b1\u03b9 \u03c4\u03bf EGFR \u03b5\u03c4\u03b5\u03c1\u03bf\u03b4\u03b9\u03bc\u03b5\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03b3\u03b9\u03b1 \u03bd\u03b1 \u03be\u03b5\u03ba\u03b9\u03bd\u03ae\u03c3\u03bf\u03c5\u03bd \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c9\u03b3\u03ae \u03c3\u03ae\u03bc\u03b1\u03c4\u03bf\u03c2, \u03ba\u03b1\u03b9 \u03cc\u03c4\u03b9 \u03ba\u03ac\u03b8\u03b5 \u03ad\u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c1\u03c5\u03b8\u03bc\u03af\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03c0\u03b1\u03c1\u03b1\u03b3\u03c9\u03b3\u03ae \u03c4\u03bf\u03c5 VEGF, \u03b8\u03b1 \u03c6\u03b1\u03b9\u03bd\u03cc\u03c4\u03b1\u03bd \u03bb\u03bf\u03b3\u03b9\u03ba\u03cc \u03bd\u03b1 \u03c3\u03c5\u03b3\u03ba\u03c1\u03af\u03bd\u03bf\u03c5\u03bc\u03b5 \u03c4\u03b1 \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03ad\u03c3\u03bc\u03b1\u03c4\u03b1 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ae\u03c2 \u03c4\u03bf\u03c5 EGFR, \u03c4\u03bf\u03c5 HER2, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5 VEGF, \u03bc\u03b5\u03bc\u03bf\u03bd\u03c9\u03bc\u03ad\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc, \u03c3\u03b5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03ad\u03c2 \u03c3\u03b5\u03b9\u03c1\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd.<\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\"><a href=\"http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2822454\/\">http:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC2822454\/<\/a><\/p>\n<p style=\"font-weight: 400;\"><a href=\"http:\/\/web.mit.edu\/hst527\/www\/readings\/Lecture%206\/VEGF.pdf\">http:\/\/web.mit.edu\/hst527\/www\/readings\/Lecture%206\/VEGF.pdf<\/a><\/p>\n<p style=\"font-weight: 400;\"><a href=\"http:\/\/theoncologist.alphamedpress.org\/content\/10\/6\/382.full.pdf+html\">http:\/\/theoncologist.alphamedpress.org\/content\/10\/6\/382.full.pdf+html<\/a><\/p>\n<p style=\"font-weight: 400;\">\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>E-CADHERIN<\/li>\n<li>NRP2<\/li>\n<li>TGF\u03b2R<\/li>\n<li>AR<\/li>\n<li>TROP2<\/li>\n<li>EPCAM<\/li>\n<\/ul>\n<ul style=\"font-weight: 400;\">\n<li>IL17BR<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">\u0397 \u03b9\u03bd\u03c4\u03b5\u03c1\u03bb\u03b5\u03c5\u03ba\u03af\u03bd\u03b7-17 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03ac \u0392 \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7 \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf IL17RB \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf. \u0388\u03c7\u03b5\u03b9 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03b7\u03b8\u03b5\u03af \u03c3\u03b5 \u03c5\u03c8\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03b5 \u03ac\u03c4\u03bf\u03bc\u03b1 \u03c0\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03ba\u03b1\u03c1\u03b4\u03b9\u03b1\u03ba\u03bf\u03cd\u03c2 \u03b9\u03bd\u03bf\u03b2\u03bb\u03ac\u03c3\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03bf\u03c1\u03b9\u03c3\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03cc\u03c0\u03c9\u03c2 : \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ae\u03c2 \u03c0\u03c1\u03bf\u03ad\u03bb\u03b5\u03c5\u03c3\u03b7\u03c2, \u03bc\u03c5\u03b5\u03bb\u03bf\u03cd \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03b8\u03cd\u03bc\u03bf\u03c5 \u03b1\u03b4\u03ad\u03bd\u03b1, \u03c3\u03c0\u03bb\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03b9\u03c3\u03c4\u03ce\u03bd. \u0397 IL-17 R  \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ac \u03b2\u03c1\u03af\u03c3\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03c3\u03c4\u03bf \u03bb\u03b5\u03c0\u03c4\u03cc \u03ad\u03bd\u03c4\u03b5\u03c1\u03bf, \u03ba\u03b1\u03b9 \u03c4\u03bf\u03c5\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03c4\u03c9\u03bd \u03c0\u03bd\u03b5\u03c5\u03bc\u03cc\u03bd\u03c9\u03bd.<\/p>\n<p style=\"font-weight: 400;\">\n<ul style=\"font-weight: 400;\">\n<li>CXCR4<\/li>\n<\/ul>\n<p style=\"font-weight: 400;\">O CXC \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b7\u03c2 \u03c4\u03cd\u03c0\u03bf\u03c5 4 (CXCR-4), \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc\u03c2 \u03c9\u03c2 \u03c6\u03bf\u03c5\u03b6\u03af\u03bd\u03b7 \u03ae CD184 (\u03c3\u03cd\u03bc\u03c0\u03bb\u03b5\u03b3\u03bc\u03b1 \u03c4\u03b7\u03c2 \u03b4\u03b9\u03b1\u03c6\u03bf\u03c1\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7\u03c2 184) \u03b5\u03af\u03bd\u03b1\u03b9 \u03bc\u03b9\u03b1\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dcxcr4%2Breceptor%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Protein&amp;usg=ALkJrhjVusi5KTxOO5XMrPvr2Da0RR_r7w\">\u03c0\u03c1\u03c9\u03c4\u03b5\u0390\u03bd\u03b7<\/a>\u00a0\u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03bd \u03ac\u03bd\u03b8\u03c1\u03c9\u03c0\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf  CXCR4\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dcxcr4%2Breceptor%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Gene&amp;usg=ALkJrhgL0S0aAtd2ZhSEhxNL7Jz2q8xoJQ\">\u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf<\/a>. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03bf CXCR4 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03bd\u03b1 \u03b2\u03c1\u03b5\u03b8\u03b5\u03af \u03c3\u03b5 \u03b1\u03b3\u03b3\u03b5\u03b9\u03b1\u03ba\u03ac \u03b5\u03bd\u03b4\u03bf\u03b8\u03b7\u03bb\u03b9\u03b1\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03ba\u03b1\u03b9\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dcxcr%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Neuronal&amp;usg=ALkJrhjfpjJ8uKQVQY69xC1tD4Pm2KNcPg\">\u03bd\u03b5\u03c5\u03c1\u03c9\u03bd\u03b9\u03ba\u03ac<\/a>\u00a0\/\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dcxcr%2Bwikipedia%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D625%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Nerve_cells&amp;usg=ALkJrhiovkFqiAPh-8XMxEtbs1ZqzW3_LQ\">\u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1<\/a>\u03a4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1 \u03c0\u03bf\u03c5 \u03bc\u03c0\u03bb\u03bf\u03ba\u03ac\u03c1\u03bf\u03c5\u03bd \u03c4\u03bf\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 CXCR4 \u03c6\u03b1\u03af\u03bd\u03b5\u03c4\u03b1\u03b9 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b9\u03ba\u03b1\u03bd\u03ac \u03bd\u03b1 \u00ab\u03ba\u03b9\u03bd\u03b7\u03c4\u03bf\u03c0\u03bf\u03b9\u03ae\u03c3\u03bf\u03c5\u03bd\u00bb \u03b1\u03b9\u03bc\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03ac \u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03ba\u03bb\u03bf\u03c6\u03bf\u03c1\u03af\u03b1 \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2, \u03cc\u03c0\u03c9\u03c2\u00a0<a href=\"http:\/\/translate.googleusercontent.com\/translate_c?hl=el&amp;prev=\/search%3Fq%3Dcxcr4%2Breceptor%26hl%3Del%26rlz%3D1W1NNVC_enGR491%26biw%3D1440%26bih%3D664%26prmd%3Dimvns&amp;rurl=translate.google.gr&amp;sl=en&amp;u=http:\/\/en.wikipedia.org\/wiki\/Peripheral_blood_stem_cells&amp;usg=ALkJrhhsLC9igOF3Tn5kJfWwyJNcdghtCQ\">\u03b2\u03bb\u03b1\u03c3\u03c4\u03b9\u03ba\u03ac \u03ba\u03cd\u03c4\u03c4\u03b1\u03c1\u03b1 \u03c0\u03b5\u03c1\u03b9\u03c6\u03b5\u03c1\u03b9\u03ba\u03bf\u03cd \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2<\/a>. \u039f CXCR4 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03c0\u03cc \u03c4\u03bf\u03c5\u03c2 \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03bc\u03b5\u03bb\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03bf\u03c5\u03c2 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03b5\u03af\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b7\u03c2, \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bd\u03b4\u03ad\u03b5\u03c4\u03b1\u03b9 \u03b5\u03ba\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03ac \u03bc\u03b5 \u03c4\u03bf\u03bd CXC \u03c3\u03c4\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1  1 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b7\u03c2 \u03c0\u03c1\u03bf\u03b5\u03c1\u03c7\u03cc\u03bc\u03b5\u03bd\u03bf \u03b1\u03c0\u03cc \u03c4\u03bf\u03bd (SDF-1), \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03b3\u03bd\u03c9\u03c3\u03c4\u03cc \u03c9\u03c2 CXCL12 (Fredriksson et al., 2003). \u039f CXCR4 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b1\u03c0\u03bf\u03ba\u03bb\u03b5\u03b9\u03c3\u03c4\u03b9\u03ba\u03ac \u03c3\u03c4\u03bf \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03cc\u03c0\u03bb\u03b1\u03c3\u03bc\u03b1, \u03b1\u03bb\u03bb\u03ac \u03b4\u03b5\u03bd \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03bf\u03bd \u03c0\u03c5\u03c1\u03ae\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7 \u03bc\u03b5\u03bc\u03b2\u03c1\u03ac\u03bd\u03b7 \u03c4\u03c9\u03bd \u03bd\u03b5\u03c6\u03c1\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5. \u039f CXCR4 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03b5\u03c0\u03af\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03ad\u03bd\u03b1 \u03b5\u03c5\u03c1\u03cd \u03c6\u03ac\u03c3\u03bc\u03b1 \u03b9\u03c3\u03c4\u03ce\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03bf\u03c5 \u03b1\u03bd\u03bf\u03c3\u03bf\u03c0\u03bf\u03b9\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03ba\u03b5\u03bd\u03c4\u03c1\u03b9\u03ba\u03ce\u03bd \u03bd\u03b5\u03c5\u03c1\u03b9\u03ba\u03ce\u03bd \u03c3\u03c5\u03c3\u03c4\u03b7\u03bc\u03ac\u03c4\u03c9\u03bd, \u03b1\u03bb\u03bb\u03ac \u03c3\u03b5 \u03c7\u03b1\u03bc\u03b7\u03bb\u03ac \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03b5\u03ba\u03c6\u03c1\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03c6\u03c5\u03c3\u03b9\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03bf\u03cd\u03c2 \u03b9\u03c3\u03c4\u03bf\u03cd\u03c2 \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03ba\u03b1\u03b9 \u03c4\u03c9\u03bd \u03c9\u03bf\u03b8\u03b7\u03ba\u03ce\u03bd. \u03a5\u03c8\u03b7\u03bb\u03ae \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 \u03c4\u03bf\u03c5 CXCL12 \u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b1\u03ba\u03b1\u03bb\u03c5\u03c6\u03b8\u03b5\u03af \u03c3\u03b5 \u03bb\u03b5\u03bc\u03c6\u03b1\u03b4\u03ad\u03bd\u03b1, \u03bc\u03c5\u03b5\u03bb\u03cc \u03c4\u03c9\u03bd \u03bf\u03c3\u03c4\u03ce\u03bd, \u03ae\u03c0\u03b1\u03c1, \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03bf\u03bd \u03b5\u03b3\u03ba\u03ad\u03c6\u03b1\u03bb\u03bf, \u03bf\u03b9 \u03bf\u03c0\u03bf\u03af\u03b5\u03c2 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bf\u03b9\u03bd\u03ad\u03c2 \u03b8\u03ad\u03c3\u03b5\u03b9\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03b1\u03c0\u03cc \u03b4\u03b9\u03ac\u03c6\u03bf\u03c1\u03bf\u03c5\u03c2 \u03ba\u03b1\u03ba\u03bf\u03ae\u03b8\u03b5\u03b9\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5\u03c2.<\/p>\n<p style=\"font-weight: 400;\">\u039f \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1\u03c2 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03ba\u03af\u03bd\u03b7\u03c2 CXCR4 \u03b1\u03bd\u03b1\u03b4\u03b5\u03b9\u03ba\u03bd\u03cd\u03b5\u03c4\u03b1\u03b9 \u03c9\u03c2 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2, \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u038c\u03c0\u03c9\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03c4\u03b9\u03c2 \u03c0\u03b5\u03c1\u03b9\u03c3\u03c3\u03cc\u03c4\u03b5\u03c1\u03b5\u03c2 \u03bc\u03bf\u03c1\u03c6\u03ad\u03c2 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5, \u03c4\u03bf \u03c0\u03c1\u03ce\u03b9\u03bc\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03c3\u03c5\u03c7\u03bd\u03ac \u03bd\u03b1 \u03b5\u03bb\u03b5\u03b3\u03c7\u03b8\u03b5\u03af \u03bc\u03b5 \u03c4\u03bf\u03c0\u03b9\u03ba\u03ac \u03ba\u03b1\u03c4\u03b5\u03c5\u03b8\u03c5\u03bd\u03cc\u03bc\u03b5\u03bd\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03ac\u03bd\u03b5\u03b9 \u03b1\u03ba\u03c4\u03b9\u03bd\u03bf\u03b2\u03bf\u03bb\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c7\u03b5\u03b9\u03c1\u03bf\u03c5\u03c1\u03b3\u03b9\u03ba\u03ae \u03b5\u03c0\u03ad\u03bc\u03b2\u03b1\u03c3\u03b7. \u0397 \u03c4\u03b1\u03c5\u03c4\u03bf\u03c0\u03bf\u03af\u03b7\u03c3\u03b7 \u03b1\u03c1\u03ba\u03b5\u03c4\u03ce\u03bd \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03c9\u03bd \u03ba\u03b9\u03bd\u03ac\u03c3\u03b7\u03c2 \u03c4\u03c5\u03c1\u03bf\u03c3\u03af\u03bd\u03b7\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03ce\u03bd \u03c3\u03c4\u03b7\u03bd \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c5\u03c0\u03bf\u03b4\u03bf\u03c7\u03ad\u03b1 \u03c4\u03bf\u03c5 \u03b5\u03c0\u03b9\u03b4\u03b5\u03c1\u03bc\u03b9\u03ba\u03bf\u03cd \u03b1\u03c5\u03be\u03b7\u03c4\u03b9\u03ba\u03bf\u03cd \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1 (EGFR), \u03ad\u03c7\u03b5\u03b9 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c3\u03c4\u03bf\u03c7\u03b5\u03c5\u03bc\u03ad\u03bd\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03b9\u03ce\u03bd, \u03c3\u03c5\u03bc\u03c0\u03b5\u03c1\u03b9\u03bb\u03b1\u03bc\u03b2\u03b1\u03bd\u03bf\u03bc\u03ad\u03bd\u03c9\u03bd \u03c4\u03c9\u03bd erlotinib \u03ba\u03b1\u03b9 cetuximab. \u03a9\u03c3\u03c4\u03cc\u03c3\u03bf, \u03b5\u03bd\u03ce \u03b1\u03c5\u03c4\u03bf\u03af \u03bf\u03b9 EGFR \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03b9 \u03ad\u03c7\u03bf\u03c5\u03bd \u03b2\u03b5\u03bb\u03c4\u03b9\u03ce\u03c3\u03b5\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 NSCLC, \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b3\u03b9\u03b1 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03c3\u03c4\u03ac\u03b4\u03b9\u03bf SCLC \u03c3\u03c4\u03b7\u03c1\u03af\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03b5\u03b3\u03ac\u03bb\u03bf \u03b2\u03b1\u03b8\u03bc\u03cc \u03c3\u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7 \u03c3\u03c4\u03b7\u03bd \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03ae \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1. \u03a3\u03c5\u03bd\u03b5\u03c0\u03ce\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b4\u03b9\u03bf\u03c1\u03af\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b4\u03b9\u03b1\u03ba\u03c1\u03b9\u03c4\u03ac \u03b2\u03b9\u03bf\u03c7\u03b7\u03bc\u03b9\u03ba\u03ac \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c4\u03bf\u03c5 SCLC \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03bf\u03b4\u03b7\u03b3\u03ae\u03c3\u03b5\u03b9 \u03c3\u03b5 \u03bd\u03ad\u03b5\u03c2 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ad\u03c2 \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03b9\u03c2 \u03ba\u03b1\u03b9 \u03b2\u03b5\u03bb\u03c4\u03af\u03c9\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b5\u03c0\u03b9\u03b2\u03af\u03c9\u03c3\u03b7\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 SCLC. \u03a0\u03c1\u03cc\u03c3\u03c6\u03b1\u03c4\u03b1, \u03ad\u03bd\u03b1\u03c2  \u03bd\u03ad\u03bf\u03c2 CXCR4 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2, AMD070 (Genzyme Corporation), \u03c6\u03ac\u03bd\u03b7\u03ba\u03b5 \u03bd\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03bd\u03b5\u03ba\u03c4\u03cc\u03c2 \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c3\u03b5 \u03c3\u03c5\u03bd\u03b4\u03c5\u03b1\u03c3\u03bc\u03cc \u03bc\u03b5 \u03c1\u03b9\u03c4\u03bf\u03bd\u03b1\u03b2\u03af\u03c1\u03b7 (\u03b1\u03bd\u03c4\u03b9-\u03b9\u03b9\u03ba\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03ad\u03b1 \u03c0\u03c1\u03c9\u03c4\u03b5\u03ac\u03c3\u03b7\u03c2) \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 HIV. \u039c\u03af\u03b1 \u03b4\u03bf\u03c3\u03bf\u03b5\u03be\u03b1\u03c1\u03c4\u03ce\u03bc\u03b5\u03bd\u03b7 \u03b1\u03cd\u03be\u03b7\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03b1\u03c1\u03b9\u03b8\u03bc\u03bf\u03cd \u03c4\u03c9\u03bd \u03bb\u03b5\u03c5\u03ba\u03ce\u03bd \u03c4\u03bf\u03c5 \u03b1\u03af\u03bc\u03b1\u03c4\u03bf\u03c2 \u03c0\u03b1\u03c1\u03b1\u03c4\u03b7\u03c1\u03ae\u03b8\u03b7\u03ba\u03b1\u03bd \u03c9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03cc\u03c2 \u03b4\u03b5\u03af\u03ba\u03c4\u03b7\u03c2 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03b9-CXCR4 \u03b4\u03c1\u03b1\u03c3\u03c4\u03b7\u03c1\u03b9\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 HIV. \u0395\u03c0\u03b9\u03c0\u03bb\u03ad\u03bf\u03bd, \u03ac\u03bb\u03bb\u03bf\u03b9 CXCR4 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03b1\u03c5\u03c4\u03ae \u03c4\u03b7 \u03c3\u03c4\u03b9\u03b3\u03bc\u03ae \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c4\u03bf\u03bd \u03b9\u03cc HIV \u03ba\u03b1\u03b9 \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u0399 \u03ba\u03b1\u03b9 \u0399\u0399 \u03c4\u03c9\u03bd \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03b4\u03bf\u03ba\u03b9\u03bc\u03ce\u03bd. \u03a4\u03bf BKT140 (Biokine Therapeutics) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03b5\u03be\u03b1\u03b9\u03c1\u03b5\u03c4\u03b9\u03ba\u03ac \u03b5\u03c0\u03b9\u03bb\u03b5\u03ba\u03c4\u03b9\u03ba\u03cc \u03c4\u03c1\u03bf\u03c0\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03bf \u03c0\u03b5\u03c0\u03c4\u03af\u03b4\u03b9\u03bf CXCR4 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2  \u03c0\u03bf\u03c5 \u03b4\u03bf\u03ba\u03b9\u03bc\u03ac\u03b6\u03b5\u03c4\u03b1\u03b9 \u03c3\u03c4\u03b7 \u03c6\u03ac\u03c3\u03b7 \u0399 \/ \u0399\u0399 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03c3\u03b5 \u03b1\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03cc \u03bc\u03c5\u03ad\u03bb\u03c9\u03bc\u03b1 . \u039f TG-0054 (TaiGen Biotechnology Co, Ltd) \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03b1\u03bd\u03c4\u03b1\u03b3\u03c9\u03bd\u03b9\u03c3\u03c4\u03ae\u03c2 CXCR4 \u03bf \u03bf\u03c0\u03bf\u03af\u03bf\u03c2 \u03c3\u03ae\u03bc\u03b5\u03c1\u03b1 \u03b1\u03be\u03b9\u03bf\u03bb\u03bf\u03b3\u03b5\u03af\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03bc\u03af\u03b1 \u03c4\u03c5\u03c7\u03b1\u03b9\u03bf\u03c0\u03bf\u03b9\u03b7\u03bc\u03ad\u03bd\u03b7,  \u03b5\u03bb\u03b5\u03b3\u03c7\u03cc\u03bc\u03b5\u03bd\u03b7 \u03bc\u03b5 \u03b5\u03b9\u03ba\u03bf\u03bd\u03b9\u03ba\u03cc \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03bf, \u03b4\u03b9\u03b1\u03b4\u03bf\u03c7\u03b9\u03ba\u03ae \u03b5\u03c6\u03ac\u03c0\u03b1\u03be \u03b5\u03bd\u03b4\u03bf\u03c6\u03bb\u03ad\u03b2\u03b9\u03b1 \u03b4\u03cc\u03c3\u03b7 \u03bc\u03b5\u03bb\u03ad\u03c4\u03b7 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03b1\u03be\u03b9\u03bf\u03bb\u03cc\u03b3\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03c3\u03c6\u03ac\u03bb\u03b5\u03b9\u03b1\u03c2, \u03c4\u03b7\u03bd \u03b1\u03bd\u03bf\u03c7\u03ae \u03ba\u03b1\u03b9 \u03c4\u03b9\u03c2 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03ba\u03b9\u03bd\u03b7\u03c4\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03b9 \u03c6\u03b1\u03c1\u03bc\u03b1\u03ba\u03bf\u03b4\u03c5\u03bd\u03b1\u03bc\u03b9\u03ba\u03ad\u03c2 \u03b9\u03b4\u03b9\u03cc\u03c4\u03b7\u03c4\u03b5\u03c2 \u03c3\u03b5 \u03c5\u03b3\u03b9\u03b5\u03af\u03c2 \u03b5\u03b8\u03b5\u03bb\u03bf\u03bd\u03c4\u03ad\u03c2.<\/p>\n<p style=\"font-weight: 400;\">\u03a4\u03bf \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9 \u03c4\u03bf\u03c5 CXCR4\/CXCL12 \u03b4\u03b9\u03b1\u03b4\u03c1\u03b1\u03bc\u03b1\u03c4\u03af\u03b6\u03b5\u03b9 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc \u03c1\u03cc\u03bb\u03bf \u03c3\u03c4\u03bf\u03bd \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03cc \u03c4\u03bf\u03c5 SCLC, \u03c4\u03b7 \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7, \u03c4\u03b7\u03bd \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03c5\u03c0\u03bf\u03c4\u03c1\u03bf\u03c0\u03ae. \u0391\u03c5\u03c4\u03ae \u03b7 \u03bf\u03b4\u03cc\u03c2 \u03bc\u03c0\u03bf\u03c1\u03b5\u03af \u03bd\u03b1 \u03c0\u03b1\u03c1\u03ad\u03c7\u03b5\u03b9 \u03bc\u03b9\u03b1 \u03bd\u03ad\u03b1 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03c5\u03c4\u03b9\u03ba\u03ae \u03c0\u03c1\u03bf\u03c3\u03ad\u03b3\u03b3\u03b9\u03c3\u03b7 \u03c3\u03c4\u03bf\u03c7\u03b5\u03cd\u03bf\u03bd\u03c4\u03b1\u03c2 \u03c4\u03b7\u03bd \u03b5\u03be\u03ad\u03bb\u03b9\u03be\u03b7 \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03be\u03ac\u03c0\u03bb\u03c9\u03c3\u03b7 \u03ba\u03b1\u03b8\u03ce\u03c2 \u03ba\u03b1\u03b9 \u03c4\u03bf \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03c0\u03c1\u03bf\u03c3\u03c4\u03b1\u03c4\u03b5\u03c5\u03c4\u03b9\u03ba\u03cc \u03bc\u03b9\u03ba\u03c1\u03bf\u03c0\u03b5\u03c1\u03b9\u03b2\u03ac\u03bb\u03bb\u03bf\u03bd \u03c4\u03bf\u03c5 \u03cc\u03b3\u03ba\u03bf\u03c5. \u039a\u03b1\u03b9\u03bd\u03bf\u03c4\u03cc\u03bc\u03bf\u03c2 \u03ad\u03c1\u03b5\u03c5\u03bd\u03b1 \u03c3\u03c4\u03b1 \u03bc\u03bf\u03bd\u03bf\u03c0\u03ac\u03c4\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7\u03c2 \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03af\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c3\u03c4\u03b7 \u03c7\u03b7\u03bc\u03b5\u03b9\u03bf\u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03b1\u03c0\u03b1\u03c1\u03b1\u03af\u03c4\u03b7\u03c4\u03b1 \u03b3\u03b9\u03b1 \u03c4\u03b7\u03bd \u03ba\u03b1\u03c4\u03b1\u03bd\u03cc\u03b7\u03c3\u03b7 \u03c4\u03b7\u03c2 \u03c0\u03b1\u03b8\u03bf\u03b3\u03ad\u03bd\u03b5\u03c3\u03b7\u03c2 \u03c4\u03bf\u03c5 \u03bc\u03b9\u03ba\u03c1\u03bf\u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03c0\u03bd\u03b5\u03cd\u03bc\u03bf\u03bd\u03b1 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c3\u03c4\u03bf\u03c7\u03bf\u03b8\u03b5\u03c4\u03b7\u03bc\u03ad\u03bd\u03c9\u03bd \u03c0\u03c1\u03bf\u03c3\u03b5\u03b3\u03b3\u03af\u03c3\u03b5\u03c9\u03bd \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1\u03c2.<\/p>\n<ul style=\"font-weight: 400;\">\n<li>ITGA4<\/li>\n<\/ul>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>&nbsp; \u0395GFR\/\u0395RBB1 Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase, is frequently overexpressed in non\u2010small cell lung cancer (NSCLC). These receptors play an important role in tumour cell survival and activated phosphorylated EGFR results in the phosphorylation of downstream proteins that cause cell proliferation, invasion, metastasis, and inhibition of apoptosis. Expression appears to be<\/p>","protected":false},"author":1,"featured_media":0,"parent":3117,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3200","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3200","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3200"}],"version-history":[{"count":2,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3200\/revisions"}],"predecessor-version":[{"id":4441,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3200\/revisions\/4441"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3117"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3200"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}