{"id":3350,"date":"2021-07-13T08:01:06","date_gmt":"2021-07-13T08:01:06","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3350"},"modified":"2021-07-17T11:00:13","modified_gmt":"2021-07-17T11:00:13","slug":"c-kit","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/knowledge-base\/c-kit\/","title":{"rendered":"C-KIT"},"content":{"rendered":"<div id=\"pl-3350\"  class=\"panel-layout\" ><div id=\"pg-3350-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3350-0\" ><div id=\"pgc-3350-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3350-0-0-0\" class=\"so-panel widget widget_orion_simple_gallery panel-first-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3350-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-orion_simple_gallery so-widget-orion_simple_gallery-base\"\n\t\t\t\n\t\t><div class=\"row orion-simple-gallery grid\">\r\n\r\n\t<div class=\"col-md-12 widget-header\">\r\n\t\t<h3 class=\"widget-title text-dark\">C-KIT<\/h3>\r\n\t<\/div>\r\n\r\n\t<div class=\"wrapper\">\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"col-lg-12 col-sm-12 col-xs-12\">\r\n\t\t\t\t<div class=\"image-w relative\">\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"overlay-none overlay-hover-none scale-none\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"457\" height=\"450\" src=\"https:\/\/www.molecular-view.com\/wp-content\/uploads\/2021\/07\/c-kit.bmp\" class=\"attachment-orion_carousel size-orion_carousel\" alt=\"\" \/>\t\t\t\t\t\t\t<div class=\"overlay\"><\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"absolute\">\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\t\t\t\t\t\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t\t\r\n\t\t\r\n\t<\/div>\r\n<\/div><\/div><\/div><\/div><div id=\"panel-3350-0-0-1\" class=\"so-panel widget widget_sow-editor panel-last-child\" data-index=\"1\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3350-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"font-weight: 400;\">\u00a0 \u00a0 \u00a0 C-KIT is a tyrosine receptor kinase expressed in various cell types during development and it has been linked to the promotion of cellular migration, proliferation and\/or survival of melanoblasts, hematopoietic progenitors and primordial germ cells. Several reports have proposed a role for the c-kit gene on carcinogenesis. Gain-of-function mutations are associated with diseases such as mastocytosis and gastrointestinal stromal tumors among others.<\/p>\n<p style=\"font-weight: 400;\">\u00a0 \u00a0 \u00a0 Mutations on c-KIT gene that cause constitutive activation of the tyrosine kinase function of c-KIT are detectable in most gastrointestinal stromal tumours (GISTs).<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>\u00a0 \u00a0 \u00a0 C-KIT is a tyrosine receptor kinase expressed in various cell types during development and it has been linked to the promotion of cellular migration, proliferation and\/or survival of melanoblasts, hematopoietic progenitors and primordial germ cells. Several reports have proposed a role for the c-kit gene on carcinogenesis. Gain-of-function mutations are associated with<\/p>","protected":false},"author":1,"featured_media":0,"parent":2927,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3350","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3350","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3350"}],"version-history":[{"count":6,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3350\/revisions"}],"predecessor-version":[{"id":3357,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3350\/revisions\/3357"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/2927"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3350"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}