{"id":3397,"date":"2021-07-13T08:27:56","date_gmt":"2021-07-13T08:27:56","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3397"},"modified":"2021-07-17T10:58:21","modified_gmt":"2021-07-17T10:58:21","slug":"top2a","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/knowledge-base\/top2a\/","title":{"rendered":"TOP2A"},"content":{"rendered":"<div id=\"pl-3397\"  class=\"panel-layout\" ><div id=\"pg-3397-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3397-0\" ><div id=\"pgc-3397-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3397-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3397-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">TOP2A<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p style=\"font-weight: 400;\">\u0397 \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7 DNA 2-\u03ac\u03bb\u03c6\u03b1 \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c0\u03bf\u03c5 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b8\u03c1\u03ce\u03c0\u03bf\u03c5\u03c2 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af\u03c4\u03b1\u03b9 \u03b1\u03c0\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf TOP2A. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03bc\u03b9\u03b1 \u03c4\u03bf\u03c0\u03bf\u03ca\u03c3\u03bf\u03bc\u03b5\u03c1\u03ac\u03c3\u03b7 DNA, \u03ad\u03bd\u03b1 \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03c0\u03bf\u03c5 \u03b5\u03bb\u03ad\u03b3\u03c7\u03b5\u03b9 \u03ba\u03b1\u03b9 \u03b1\u03bb\u03bb\u03ac\u03b6\u03b5\u03b9 \u03c4\u03b9\u03c2 \u03c4\u03bf\u03c0\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ad\u03c2 \u03ba\u03b1\u03c4\u03b1\u03c3\u03c4\u03ac\u03c3\u03b5\u03b9\u03c2 \u03c4\u03bf\u03c5 DNA \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03b4\u03b9\u03ac\u03c1\u03ba\u03b5\u03b9\u03b1 \u03c4\u03b7\u03c2 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae\u03c2. \u0391\u03c5\u03c4\u03cc \u03c4\u03bf \u03c0\u03c5\u03c1\u03b7\u03bd\u03b9\u03ba\u03cc \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03b5\u03bc\u03c0\u03bb\u03ad\u03ba\u03b5\u03c4\u03b1\u03b9 \u03c3\u03b5 \u03b4\u03b9\u03b1\u03b4\u03b9\u03ba\u03b1\u03c3\u03af\u03b5\u03c2 \u03cc\u03c0\u03c9\u03c2 \u03b7 \u03c3\u03c5\u03bc\u03c0\u03cd\u03ba\u03bd\u03c9\u03c3\u03b7 \u03c7\u03c1\u03c9\u03bc\u03bf\u03c3\u03c9\u03bc\u03ac\u03c4\u03c9\u03bd, \u03bf \u03b4\u03b9\u03b1\u03c7\u03c9\u03c1\u03b9\u03c3\u03bc\u03cc\u03c2 \u03c7\u03c1\u03c9\u03bc\u03b1\u03c4\u03b9\u03b4\u03af\u03c9\u03bd \u03ba\u03b1\u03b9 \u03b7 \u03b1\u03bd\u03b1\u03ba\u03bf\u03cd\u03c6\u03b9\u03c3\u03b7 \u03c4\u03bf\u03c5 \u03c3\u03c4\u03c1\u03b5\u03c0\u03c4\u03b9\u03ba\u03bf\u03cd \u03c3\u03c4\u03c1\u03b5\u03c2 \u03c0\u03bf\u03c5 \u03c3\u03c5\u03bc\u03b2\u03b1\u03af\u03bd\u03b5\u03b9 \u03ba\u03b1\u03c4\u03ac \u03c4\u03b7 \u03bc\u03b5\u03c4\u03b1\u03b3\u03c1\u03b1\u03c6\u03ae \u03ba\u03b1\u03b9 \u03b1\u03bd\u03c4\u03b9\u03b3\u03c1\u03b1\u03c6\u03ae \u03c4\u03bf\u03c5 DNA. \u039a\u03b1\u03c4\u03b1\u03bb\u03cd\u03b5\u03b9 \u03c4\u03bf \u03c0\u03b1\u03c1\u03bf\u03b4\u03b9\u03ba\u03cc \u03c3\u03c0\u03ac\u03c3\u03b9\u03bc\u03bf \u03ba\u03b1\u03b9 \u03c4\u03b7\u03bd \u03b5\u03c0\u03b1\u03bd\u03b1\u03c3\u03cd\u03bd\u03b4\u03b5\u03c3\u03b7 \u03b4\u03cd\u03bf \u03ba\u03bb\u03ce\u03bd\u03c9\u03bd \u03b4\u03b9\u03c0\u03bb\u03bf\u03cd DNA \u03c0\u03bf\u03c5 \u03b5\u03c0\u03b9\u03c4\u03c1\u03ad\u03c0\u03b5\u03b9 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03ba\u03bb\u03ce\u03bd\u03bf\u03c5\u03c2 \u03bd\u03b1 \u03c0\u03b5\u03c1\u03ac\u03c3\u03bf\u03c5\u03bd \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5\u03c2, \u03b1\u03bb\u03bb\u03ac\u03b6\u03bf\u03bd\u03c4\u03b1\u03c2 \u03ad\u03c4\u03c3\u03b9 \u03c4\u03b7\u03bd \u03c4\u03bf\u03c0\u03bf\u03bb\u03bf\u03b3\u03af\u03b1 \u03c4\u03bf\u03c5 DNA. \u03a4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03c0\u03bf\u03c5 \u03ba\u03c9\u03b4\u03b9\u03ba\u03bf\u03c0\u03bf\u03b9\u03b5\u03af \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03ad\u03bd\u03b6\u03c5\u03bc\u03bf \u03bb\u03b5\u03b9\u03c4\u03bf\u03c5\u03c1\u03b3\u03b5\u03af \u03c9\u03c2 \u03c3\u03c4\u03cc\u03c7\u03bf\u03c2 \u03b3\u03b9\u03b1 \u03c0\u03bf\u03bb\u03bb\u03bf\u03cd\u03c2 \u03b1\u03bd\u03c4\u03b9\u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03bf\u03cd\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b5\u03c2 \u03ba\u03b1\u03b9 \u03bc\u03b9\u03b1 \u03c0\u03bf\u03b9\u03ba\u03b9\u03bb\u03af\u03b1 \u03bc\u03b5\u03c4\u03b1\u03bb\u03bb\u03ac\u03be\u03b5\u03c9\u03bd \u03c3\u03b5 \u03b1\u03c5\u03c4\u03cc \u03c4\u03bf \u03b3\u03bf\u03bd\u03af\u03b4\u03b9\u03bf \u03ad\u03c7\u03bf\u03c5\u03bd \u03c3\u03c5\u03c3\u03c7\u03b5\u03c4\u03b9\u03c3\u03c4\u03b5\u03af \u03bc\u03b5 \u03c4\u03b7\u03bd \u03b1\u03bd\u03ac\u03c0\u03c4\u03c5\u03be\u03b7 \u03c4\u03b7\u03c2 \u03b1\u03bd\u03c4\u03bf\u03c7\u03ae\u03c2 \u03c3\u03c4\u03b1 \u03c6\u03ac\u03c1\u03bc\u03b1\u03ba\u03b1.<\/p>\n<p style=\"font-weight: 400;\">\u0397 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03c4\u03b9\u03ba\u03ae \u03ba\u03b1\u03c4\u03ac\u03c3\u03c4\u03b1\u03c3\u03b7 \u03c4\u03c9\u03bd \u03ba\u03b1\u03c1\u03ba\u03b9\u03bd\u03b9\u03ba\u03ce\u03bd \u03ba\u03c5\u03c4\u03c4\u03ac\u03c1\u03c9\u03bd \u03b5\u03af\u03bd\u03b1\u03b9 \u03ad\u03bd\u03b1\u03c2 \u03c3\u03b7\u03bc\u03b1\u03bd\u03c4\u03b9\u03ba\u03cc\u03c2 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b5\u03c5\u03b1\u03b9\u03c3\u03b8\u03b7\u03c3\u03af\u03b1\u03c2 \u03c3\u03c4\u03bf\u03c5\u03c2 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 TOP2A \u03ba\u03b1\u03b9 \u03c5\u03c0\u03ac\u03c1\u03c7\u03b5\u03b9 \u03c3\u03c5\u03c3\u03c7\u03ad\u03c4\u03b9\u03c3\u03b7 \u03bc\u03b5\u03c4\u03b1\u03be\u03cd \u03c4\u03bf\u03c5 \u03c0\u03bf\u03bb\u03bb\u03b1\u03c0\u03bb\u03b1\u03c3\u03b9\u03b1\u03c3\u03bc\u03bf\u03cd, \u03c4\u03bf\u03c5 \u03c3\u03c4\u03b1\u03b4\u03af\u03bf\u03c5 \u03c4\u03bf\u03c5 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03b9\u03ba\u03bf\u03cd \u03ba\u03cd\u03ba\u03bb\u03bf\u03c5 \u03ba\u03b1\u03b9 \u03c4\u03b7\u03c2 \u03ba\u03c5\u03c4\u03c4\u03b1\u03c1\u03bf\u03c4\u03bf\u03be\u03b9\u03ba\u03cc\u03c4\u03b7\u03c4\u03b1\u03c2. \u039f\u03b9 \u03b1\u03bd\u03b1\u03c3\u03c4\u03bf\u03bb\u03b5\u03af\u03c2 \u03c4\u03bf\u03c5 TOP2A \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03bb\u03b9\u03bd\u03b9\u03ba\u03ac \u03b1\u03c0\u03bf\u03c4\u03b5\u03bb\u03b5\u03c3\u03bc\u03b1\u03c4\u03b9\u03ba\u03bf\u03af \u03c3\u03c4\u03b7 \u03b4\u03b9\u03b1\u03c7\u03b5\u03af\u03c1\u03b9\u03c3\u03b7 \u03b1\u03b9\u03bc\u03b1\u03c4\u03bf\u03bb\u03bf\u03b3\u03b9\u03ba\u03ce\u03bd \u03ba\u03b1\u03ba\u03bf\u03b7\u03b8\u03b5\u03b9\u03ce\u03bd \u03ba\u03b1\u03b9 \u03c3\u03c5\u03bc\u03c0\u03b1\u03b3\u03ce\u03bd \u03cc\u03b3\u03ba\u03c9\u03bd. \u0397 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7 TOP2A \u03b5\u03af\u03bd\u03b1\u03b9 \u03ba\u03b1\u03b8\u03bf\u03c1\u03b9\u03c3\u03c4\u03b9\u03ba\u03cc\u03c2 \u03c0\u03b1\u03c1\u03ac\u03b3\u03bf\u03bd\u03c4\u03b1\u03c2 \u03b1\u03c0\u03cc\u03ba\u03c1\u03b9\u03c3\u03b7\u03c2 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03c0\u03bf\u03c5 \u03c0\u03b5\u03c1\u03b9\u03ad\u03c7\u03b5\u03b9 \u03b1\u03bd\u03b8\u03c1\u03b1\u03ba\u03c5\u03ba\u03bb\u03af\u03bd\u03b7. \u0391\u03c3\u03b8\u03b5\u03bd\u03b5\u03af\u03c2 \u03bc\u03b5 \u03c0\u03c1\u03bf\u03c7\u03c9\u03c1\u03b7\u03bc\u03ad\u03bd\u03bf \u03ba\u03b1\u03c1\u03ba\u03af\u03bd\u03bf \u03c4\u03bf\u03c5 \u03bc\u03b1\u03c3\u03c4\u03bf\u03cd \u03c0\u03bf\u03c5 \u03b5\u03bc\u03c6\u03b1\u03bd\u03af\u03b6\u03bf\u03c5\u03bd \u03c5\u03c8\u03b7\u03bb\u03cc\u03c4\u03b5\u03c1\u03b1 \u03b5\u03c0\u03af\u03c0\u03b5\u03b4\u03b1 \u03ad\u03ba\u03c6\u03c1\u03b1\u03c3\u03b7\u03c2 TOP2A \u03b1\u03bd\u03c4\u03b1\u03c0\u03bf\u03ba\u03c1\u03af\u03b8\u03b7\u03ba\u03b1\u03bd \u03ba\u03b1\u03bb\u03cd\u03c4\u03b5\u03c1\u03b1 \u03c3\u03c4\u03b7 \u03b8\u03b5\u03c1\u03b1\u03c0\u03b5\u03af\u03b1 \u03bc\u03b5 \u03b4\u03bf\u03be\u03bf\u03c1\u03bf\u03c5\u03b2\u03b9\u03ba\u03af\u03bd\u03b7 (<a href=\"http:\/\/mct.aacrjournals.org\/search?author1=Virginie+Durbecq&amp;sortspec=date&amp;submit=Submit\">Durbecq<\/a>\u00a0et al., 2004, Burgess et al., 2008).<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>DNA topoisomerase 2-alpha is an\u00a0enzyme\u00a0that in humans is encoded by the\u00a0TOP2A\u00a0gene. This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and<\/p>","protected":false},"author":1,"featured_media":0,"parent":2927,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3397","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3397","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3397"}],"version-history":[{"count":4,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3397\/revisions"}],"predecessor-version":[{"id":3856,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3397\/revisions\/3856"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/2927"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3397"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}