{"id":3400,"date":"2021-07-13T09:51:40","date_gmt":"2021-07-13T09:51:40","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3400"},"modified":"2021-07-13T10:27:44","modified_gmt":"2021-07-13T10:27:44","slug":"bcl2","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/knowledge-base\/bcl2\/","title":{"rendered":"BCL2"},"content":{"rendered":"<div id=\"pl-3400\"  class=\"panel-layout\" ><div id=\"pg-3400-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3400-0\" ><div id=\"pgc-3400-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3400-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3400-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">BCL2<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>Bcl-2 ( B-cell lymphoma 2 ) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene . The Bcl-2 gene has been implicated in a number of cancers , including melanoma , breast , prostate , chronic lymphocytic leukemia , and lung carcinomas , as well as schizophrenia and autoimmunity . It is also thought to be involved in resistance to conventional cancer treatment. This suggests that decreased apoptosis may play a role in the development of cancer. Bcl-2 inhibitors include: an antisense oligonucleotide drug Genasense, \u0391\u0392\u03a4-737 which is one(among many so-called BH3) mimetic small molecule inhibitors which may prove valuable in the therapy of lymphoma and other blood cancers, \u0391\u0392\u03a4-199 which is applied on patients with chronic lymphocytic leukemia and Obatoclax (GX15-070)\u00a0\u00a0which has phase II results for small-cell lung cancer.<\/p>\n<\/div>\n<\/div><\/div><\/div><div id=\"panel-3400-0-0-1\" class=\"so-panel widget widget_orion_simple_gallery panel-last-child\" data-index=\"1\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3400-0-0-1\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-orion_simple_gallery so-widget-orion_simple_gallery-base\"\n\t\t\t\n\t\t><div class=\"row orion-simple-gallery grid\">\r\n\r\n\r\n\t<div class=\"wrapper\">\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"col-lg-12 col-sm-12 col-xs-12\">\r\n\t\t\t\t<div class=\"image-w relative\">\r\n\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<div class=\"overlay-none overlay-hover-none scale-none\">\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"474\" height=\"452\" src=\"https:\/\/www.molecular-view.com\/wp-content\/uploads\/2021\/07\/bcl.bmp\" class=\"attachment- size-\" alt=\"\" \/>\t\t\t\t\t\t\t<div class=\"overlay\"><\/div>\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\r\n\t\t\t\t\t\t\t\r\n\t\t\t\t\t\r\n\t\t\t\t\t<div class=\"absolute\">\r\n\t\t\t\t\t\t\r\n\t\t\t\t\t<\/div>\t\t\t\t\t\r\n\t\t\t\t<\/div>\r\n\t\t\t<\/div>\r\n\t\t\t\t\r\n\t\t\r\n\t<\/div>\r\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>Bcl-2 ( B-cell lymphoma 2 ) is the founding member of the Bcl-2 family of apoptosis regulator proteins encoded by the BCL2 gene . The Bcl-2 gene has been implicated in a number of cancers , including melanoma , breast , prostate , chronic lymphocytic leukemia , and lung carcinomas , as well as schizophrenia<\/p>","protected":false},"author":1,"featured_media":0,"parent":2927,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3400","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3400","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3400"}],"version-history":[{"count":4,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3400\/revisions"}],"predecessor-version":[{"id":3429,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3400\/revisions\/3429"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/2927"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3400"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}