{"id":3441,"date":"2021-07-13T10:18:28","date_gmt":"2021-07-13T10:18:28","guid":{"rendered":"https:\/\/www.molecular-view.com\/?page_id=3441"},"modified":"2021-07-17T11:02:13","modified_gmt":"2021-07-17T11:02:13","slug":"e-cadherin","status":"publish","type":"page","link":"https:\/\/www.molecular-view.com\/el\/knowledge-base\/e-cadherin\/","title":{"rendered":"E-cadherin"},"content":{"rendered":"<div id=\"pl-3441\"  class=\"panel-layout\" ><div id=\"pg-3441-0\"  class=\"panel-grid panel-has-style\" ><div class=\"divider-no-animation panel-row-style panel-row-style-for-3441-0\" ><div id=\"pgc-3441-0-0\"  class=\"panel-grid-cell\" ><div id=\"panel-3441-0-0-0\" class=\"so-panel widget widget_sow-editor panel-first-child panel-last-child\" data-index=\"0\" ><div class=\"orion custom default panel-widget-style panel-widget-style-for-3441-0-0-0\" ><div\n\t\t\t\n\t\t\tclass=\"so-widget-sow-editor so-widget-sow-editor-base\"\n\t\t\t\n\t\t><h3 class=\"widget-title\">E-cadherin<\/h3>\n<div class=\"siteorigin-widget-tinymce textwidget\">\n\t<p>E-cadherin is a calcium-dependent cell-cell adhesion molecule with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As founder member of the cadherin superfamily, it has been extensively investigated. There are several mechanisms that disrupt E-cadherin function in cancer: inactivating somatic and germline mutations, epigenetic silencing by DNA methylation and epithelial to mesenchymal transition-inducing transcription factors, and dysregulated protein processing.<\/p>\n<\/div>\n<\/div><\/div><\/div><\/div><\/div><\/div><\/div>","protected":false},"excerpt":{"rendered":"<p>E-cadherin is a calcium-dependent cell-cell adhesion molecule with pivotal roles in epithelial cell behavior, tissue formation, and suppression of cancer. As founder member of the cadherin superfamily, it has been extensively investigated. There are several mechanisms that disrupt E-cadherin function in cancer: inactivating somatic and germline mutations, epigenetic silencing by DNA methylation and epithelial to<\/p>","protected":false},"author":1,"featured_media":0,"parent":2927,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"class_list":["post-3441","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3441","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/comments?post=3441"}],"version-history":[{"count":1,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3441\/revisions"}],"predecessor-version":[{"id":3443,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/3441\/revisions\/3443"}],"up":[{"embeddable":true,"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/pages\/2927"}],"wp:attachment":[{"href":"https:\/\/www.molecular-view.com\/el\/wp-json\/wp\/v2\/media?parent=3441"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}