Molecular analysis of head and neck biopsy for prognosis and targeted therapy

Relative gene expression

Relative quantitative gene expression for response to chemotherapy

 BCRP (platinum,irinotecan,topotecan)
 MRP1 (cyclophoshamide,etoposide,vincristine)
 ERCC1,BRCA1 (platinum)
 TYMS (5-FU,capecitabine,pemetrexed)
 PGP(doxorubicin,paclitaxel,etoposide,vincristine)
 RRΜ1,RRΜ2,HUR (gemcitabine)
 TUBB3,SPARC,TLE3,TAU (taxanes)
 MGMT (temozolomide)

HIGH EXPRESSION -> NO RESPONSE

TOPO2A

(doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION -> RESPONSE