Molecular analysis of lung tumor sample or lung FNA sample for prognosis and targeted therapy

Relative gene expression

Relative quantitative gene expression for prediction of response to chemotherapy

 BCRP (platinum,irinotecan,topotecan)
 MRP1 (cyclophoshamide,etoposide,vincristine)
 ERCC1,BRCA1 (platinum)
 TYMS (5-FU,capecitabine,pemetrexed)
 PGP(doxorubicin,paclitaxel,etoposide,vincristine)
 RRΜ1,RRΜ2,HUR (gemcitabine)
 TUBB3,SPARC,TLE3,TAU (taxanes)
 MGMT (temozolomide)

HIGH EXPRESSION -> NO RESPONSE

TOPO2A

(doxorubicin,epirubicin)

TOPO1

(irinotecan,etoposide)

HIGH EXPRESSION -> RESPONSE